Paper Title
CURCUMIN-BASED IMIDAZO[2,1-B]THIAZOLE DERIVATIVES ARE SYNTHESISED, AND THEY ARE BIOLOGICALLY TESTED AS ANTIPROLIFERATIVE DRUGSAbstract
Inspired by the antiproliferative potential of curcumin and imidazothiazoles, a variety of curcumin-based imidazo[2,1-b] thiazole derivatives have been synthesised, described, and assessed for their anticancer efficacy against a number of different human cancer cell lines. It has been discovered that the chemicals that were produced exhibit activity ranging from significant to moderate. As a result, compounds 8a and 8g exhibit significant cytotoxicity against the A549 cell line, with IC50 values of 7.2 M and 4.7 M, respectively. In addition, compounds 8a, 8b, and 8g have been shown to have a significant amount of cytotoxicity when tested against the HeLa cell line, with their individual IC50 values ranging from 9.1 to 9.9 microM. It is interesting to note that compounds 8a and 8g both show significant cytotoxicity against the DU145 cancer cell line, with IC50 values ranging between 7.5 and 8.7 microM, respectively. In all, four different compounds (8a, 8b, 8g, and 8h) have been shown to have IC50 values that are lower than 10 M when tested against certain human cancer cell lines. They might be examined more thoroughly in order to learn more about their method of action and several other aspects.
KEYWORDS : Cytotoxicity and antiproliferative activity are some of the keywords that have been associated with curcumin.