Paper Title

FLUORIDE ASSESSMENT AND CHARACTERIZATION OF DRINKING WATERS IN JHABUA DISTRICT OF MADHYA PRADESH

Abstract

Humans need water. Life need water. Drinking, irrigation, hydroelectricity, industry, transit, sanitation, leisure, and more require water. Nonetheless, most water is utilized for drinking and farming. Hence, clean water is vital to life. Ground water is rainwater that seeps through soil pores, joints, and rock fractures. Groundwater supplies drinking, household, and 60% of the nation\'s farmland irrigation (FAI 2011). Life need water. It covers approximately three fourths of the planet and is odorless and tasteless. 2.5% of Earth\'s water is fresh, while 98.8% is ice and groundwater. Groundwater provides most drinking and agricultural water on Earth. Ground water with excessive dissolved ions is unsafe for home usage. Groundwater contains anions such carbonate, bicarbonate, chloride, sulphate, and cations like sodium, potassium, calcium, and magnesium. Water also includes minor levels of lithium, fluoride, nitrate, selenium, and arsenic. Excess of each ion depletes or poisons soil, plants, animals, and humans, posing health risks. These particular ions affect water quality and agricultural irrigation. Water provides micronutrients to humans and animals. Long-term supplementation of drinking water ions like fluoride and selenium improves health. Fluoride is important for animal and human development since. In some states, low water-supplemented fluoride is good for health. Unfortunately, much fluoride degrades drinking water and causes fluorosis and other health issues in children. Fluoride isn\'t needed by plants.
KEYWORDS : Fluorosis, Defluorination, Fluoride, Groundwater.

Paper Title

AN ANALYSIS OF MEDICINAL HERBS WITH ANTIFERTILITY PROPERTIES

Abstract

Synthetic steroidal contraceptives may cause gonad toxicity, temporary or permanent infertility, testicular germ cell cancer, breast/prostate cancer, brain developmental issues, endometriosis, and early puberty. These hazards have spurred molecular development. Hence, herbal antifertility remedies are essential. Many modern medications are isolated from nature, which has given medicinal chemicals for millennia. Hindu doctors recognized plants were contraceptive, abortifacient, and anti-implantation. Male and female animal models have tested medicinal plant extracts and active compounds for antifertility. This review updates anti-fertility herbs for men and women. Plant anti-fertility research is reviewed here. Herbal contraceptives suppress fertility and are better for women who can\'t use modern contraception due to negative effects. Researchers may find anti-fertility herbs here.
KEYWORDS : Herbal contraceptives, population explosion, birth control, antifertility, medicinal herbs.

Paper Title

ENVIRONMENTAL RESERVOIRS AND MECHANISMS OF PERSISTENCE OF VIBRIO CHOLERAE

Abstract

Vibrio cholerae, which causes cholera, is now known to be acquired from ambient sources between epidemics. This bacteria can now be found outside of endemic locations because to developments in molecular technology. V. cholerae persists in aquatic environments by intra- and interspecific mechanisms such responsive gene regulation, biofilm formation on biotic and abiotic surfaces, and interactions with many other species. This review discusses how this bacteria survives in the environment. We will describe how V. cholerae survives hunger, temperature, and salinity changes and heterotrophic protist predation.
KEYWORDS : protozoa, biofilms, chitin, zooplankton, predation, stress, starvation adaptation, viable but non- culturable

Paper Title

STUDY ON ETHNOMEDICINAL PLANTS AND PLANT PARTS SOLD IN THE LOCAL MARKET IN ALIRAJPUR DISTRICT, MADHYA PRADESH

Abstract

The Alirajpur district is located in Madhya Pradesh\'s far westernmost region. In communities, ethnobotanical surveys were conducted. The current research lists 11 ethnomedicinal herbs that local herbalists recommend and are sold locally.
KEYWORDS : Ethnomedicinal, Market Survey

Paper Title

THE AQUATIC INSECT COMMUNITY IN GWALIOR DISTRICT, MADHYA PRADESH: A BIODIVERSITY STUDY

Abstract

Insects that spend a portion of their life cycle in water are said to be aquatic. Aquatic insects play a key role in the environment and are an important food source for fish and amphibians. More than 500 species of water insects, mostly Ephimeroptera, Odonta, and Trichoptera, may be found in India\'s inland marshes. From August 2019 to November 2019, the research was carried out in the early morning hours. For the research, three locations—a vegetation site, an agricultural location, and a damaged vegetation location—were chosen. The list of water insects that have been seen includes information on their taxonomy, order, family, scientific name, and common name. In three distinct locations, a total of 24 species of aquatic insects were discovered. The research of insect populations at several locations showed that abiotic and biotic variables controlled the number of aquatic insects.
KEYWORDS : Diversity; Aquatic Insects; Environment; Habitat;

Paper Title

A COMPREHENSIVE EVALUATION OF ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY

Abstract

Modern techniques like UPLC provide liquid chromatography a fresh outlook. When compared to high-performance liquid chromatography (HPLC), ultra-performance liquid chromatography (UPLC) is more accurate, faster, and more sensitive. The pharmaceutical business has been concentrating on innovative strategies to boost the economics and speed up medication production for the last 21 years. In the UPLC, separation and measurement are carried out at very high pressures (up to 100M Pa). When compared to HPLC, it is observed that high pressure has little to no influence on the analytical column, while other factors like time loss and melting are minimal.
KEYWORDS : UPLC (Ultra performance liquid chromatography), High pressure, High separation efficiency.

Paper Title

PHARMACEUTICAL ANALYSIS: ADVANCED CHROMATOGRAPHIC AND SPECTROSCOPIC METHODS

Abstract

Today, chromatographic methods detect and quantify mixture components. All research labs, pharmaceutical companies, universities, and others employ chromatography for separation science. Drug development needs a technology that allows scientists study drug molecules accurately, precisely, and easily. Chromatography uses stationary and mobile phases to separate a mixture. This work helps the authors comprehend spectroscopic and chromatographic methods used in medication development. This study discusses HPLC, TLC, UPLC, UV-Visible, IR, and NMR spectroscopic and chromatographic procedures used to analyze pharmaceutical items.
KEYWORDS : Chromatography, analytical techniques, spectroscopic techniques,

Paper Title

A REVIEW OF NUTRITIOUS COSMETICS FOR HAIR AND SKIN

Abstract

In recent years, the usage of cosmetics has increased significantly. They are also referred to as cosmeceuticals or nutritious cosmetics. The most common name for nutricosmetics is cosmetics. The most promising, although difficult, therapy alternatives accessible to doctors are cosmetics and nutricosmetics. These days, cosmetics having antiaging properties are referred to as cosmeceuticals. They are the market sector with the quickest growth. Even if these cosmetics are pricey, many are willing to spend money on them in order to realize their desire to seem younger. Because of their increasing popularity, it is clear that they are the intersection of health and beauty. For certain skin issues including photoaging, hyperpigmentation, and wrinkles, cosmetic treatments are available. These are cosmetic items that include biologically active ingredients that have therapeutic or drug-like effects. Cosmeceuticals have been shown to be beneficial in treating a variety of dermatological disorders and are known to nourish the skin as well as enhance its look.
KEYWORDS : Nutricosmetics, Hyperpigmentation.

Paper Title

A REVIEW OF THE PARTICLE DIMENSION MEASUREMENT FOR NASAL DRUG DELIVERY SYSTEMS

Abstract

Decongestants and antihistamines are often administered nasally. However, nasal delivery of systemically active drugs is becoming popular. In pain and migraine treatment, vaccination distribution, and osteoporosis treatment, the turbinate and lymphoid tissues in the back of the nasal cavity allow for rapid and targeted medicine absorption. For Alzheimer\'s disease medicine administration, the olfactory region provides direct access to the central nervous system. Conventional nasal spray is used most. Their median particle size is 30–120 microns for nasal deposition. Bigger droplets settle on the nose, while microscopic particles may travel deeper. Characterizing the sub-ten micron fraction helps assess lung drug delivery risk. The FDA\'s draft guidance, \"Bioavailability and Bioequivalence Studies for Nasal Aerosols and Nasal Sprays for Local Action\" (April 2003), recommends laser diffraction for particle size distribution measurements. Cascade impaction is recommended for distribution analysis. This study covers these two complementary methodologies and shows how they may be used together to generate nasal product evaluation data.
KEYWORDS : Next Generation Pharmaceutical Impactor, Andersen Cascade Impactor, Inertial technique, Laser Diffraction.

Paper Title

A REVIEW OF FLAVONOIDS AND OTHER PHENOLIC SUBSTANCES FROM MEDICINAL PLANTS FOR PHARMACOLOGICAL AND THERAPEUTIC USES

Abstract

Antioxidants and bioactive molecules called flavonoids and phenolic compounds have been explored for their potential to treat and prevent a wide range of ailments. In this work, interesting alternative sources for pharmacological and therapeutic uses are reviewed, including flavonoids and other phenolic compounds. The potential use of these phytochemicals from medicinal plants, particularly for health promotion, in pharmaceutical and medical fields are also discussed. They have anti-inflammatory, antioxidant, anti-cancer, cardioprotective, immune-system-boosting, and UV protection properties.
KEYWORDS : Flavonoid; medicinal and pharmaceutical applications; medicinal plants; phenolics

Paper Title

DESIGN AND SYNTHESIS OF BENZOPYRONE COMPOUNDS WITH POTENTIAL MEDICINAL APPLICATIONS

Abstract

The benzopyrones are a significant class of compounds that have potential uses in the medical field. They display a diverse array of biological activities, some of which include anti-inflammatory, antioxidant, anticoagulant, antiviral, and anticancer properties. In the course of this research, we devised and synthesized a wide range of new benzopyrone compounds in order to investigate the possible medical uses of these substances. The Michael addition reactions, the Claisen-Schmidt condensation, and the Knoevenagel condensation were among the several methods that were used in the synthesis of the benzopyrone derivatives. Many different types of spectroscopy, such as 1H-NMR, 13C-NMR, and IR spectroscopy, were used in order to investigate the structural make-up of the newly synthesized compounds. In vitro and in vivo examinations of the synthetic benzopyrone compounds\' biological activity yielded exciting findings on the latter\'s possible use in the treatment of a variety of diseases. The findings of this research provide useful information that may be used to the formulation and synthesis of new benzopyrone molecules that could have uses in medicine.
KEYWORDS : Benzopyrone, anti-inflammatory, antioxidant, anticoagulant, antiviral, and anticancer properties

Paper Title

A DISCUSSION ON THE ROLE OF COMPOSITE LIPOSOMAL TECHNOLOGIES IN THE DELIVERY OF SPECIALIZED DRUGS

Abstract

Liposomes and polymeric scaffolds may revolutionize medication delivery. Liposomes are a promising bioactive drug delivery technology, but they face several barriers to widespread medical application. Two methods can address liposomes\' poor medicine delivery. The first adds functional moieties to liposome surfaces, while the second integrates depot polymeric scaffolding with pre-encapsulated drug-loaded liposomes. This seeks creative alternatives to standard liposomes\' short plasma half-lives, toxicity, instability, and poor drug release control over time. This paper describes how depot polymeric scaffolds and liposome technology may alleviate the disadvantages of standard liposomes for therapeutic purposes.
KEYWORDS :

Paper Title

A CRITICAL ANALYSIS OF ANALYTICAL DESIGN QUALITY

Abstract

With predetermined goals as its starting point, the quality-by-design (QbD) method employs science and risk management techniques to build a knowledge of the product and process, leading to process control. Analytical techniques may be included in the QbD paradigm. The AQbD methodology places a strong focus on having a thorough grasp of the workings of and factors influencing the analytical methods used in product development. Utilizing the numerous tools and approaches covered in the essay, the factors that have an impact on the output are discovered and thoroughly risk assessed before being optimized. A control strategy is implemented once the final procedure has been verified. To speed up the process of accepting this distinctive and successful methodology, worldwide standardization of QbD nomenclature and precise recommendations on application of the QbD approach in all domains of product development, including analytical techniques, are also required.
KEYWORDS : Quality, Quality by Design, Analytical QbD, MODR.

Paper Title

STUDY ON ENHANCING THE SOLUBILITY OF AN INADEQUATELY WATER-SOLUBLE DRUG

Abstract

One crucial factor in achieving the optimum medication concentration in the bloodstream so that a pharmacological reaction may be seen is solubility. Since poorly soluble medications have limited absorption and bioavailability, it is crucial to increase their solubility and dissolving rate. The bioavailability of around 40% of all novel chemical entities is low. One of the main difficulties for formulation scientists in the future will be to increase the bioavailability of medications that aren\'t easily soluble. This review tries to focus on the polymers used to achieve solubility enhancement, process of solubilization, and factors that affect it in addition to discussing the various traditional novel techniques like sono crystallization, spray freezing in to liquid, pearl milling, solid dispersion, salt formation, and pH adjustment for solubility enhancement of hydrophobic drugs for oral pharmaceutical formulation. In this article, we concentrated on how important solubility of the medication is to achieving adequate bioavailability following drug absorption, making it the most important component in formulation creation.
KEYWORDS : Solubility Enhancement, Poorly Water Soluble Drug,

Paper Title

A REVIEW OF BCS CLASS II DRUGS AND STRATEGIES FOR IMPROVEMENT IN SOLUBILITY

Abstract

This review article\'s goal is to provide a concise summary of the research on possible excipient effects on intestinal medication permeability and transit. Despite excipients being used in prescription products for decades, a lot of study has been put into determining how they could affect medication bioavailability. Drug formulation modifications, might raise potential excipient problems. The in vivo requirement, also known as a biowaiver, may be waived for certain oral products as a consequence of regulatory authorities\' establishment of in vivo bioequivalence requirements. The biopharmaceutics classification system is used to characterize the drug substance and drug product in vitro as part of the biowaiver acceptance criteria. Regarding BCS-based biowaivers, many regulatory advice papers have been published; as a result, the most recent FDA guideline is more stringent than earlier guidance, particularly with relation to excipient risk. Particularly, sugar alcohols have been mentioned as possible excipients that might affect absorption. Here, the hazards of these biowaivers and excipients are covered.
KEYWORDS : API, Excipients, Bioavailability, BCS Class drug II.

Paper Title

EFFECTIVENESS OF A PLANNED TEACHING PROGRAM ON THE ILL EFFECTS OF SELFIE-TAKING BEHAVIOR ON HEALTH AMONG NURSING STUDENTS AT A SELECTED NURSING COLLEGE IN BANGALORE

Abstract

Background: Smart phones are no longer only a communication device but serve as a substitute for the home computer and have internet related access as well as a camera that with its high resolution now substitutes the camera we call it as “Selfie camera”. Selfie have now become a major trend and smart phone manufacturers are ensuring that they provide good front cameras in phone and technology is adapting this social trend of self portraits to rule the world. Method: For this study, an evaluative technique was applied. The data is collected using a one-group pre-test and post-test design. The planned teaching programme regarding ill effects selfie taking behavior on health was the study\'s independent variable, while the attitude of nursing students regarding Selfie taking behavior and its impact on health was the dependent variable. The study was conducted from June 2022 to august 2022 among 60 subjects; the collected data was analyzed and interpreted using descriptive and inferential statistics. Results: The present study reveals that the overall behavioral scores of respondents were found to be 51.33% with standard deviation 4.59 in pre test. The overall behavioral scores of respondents were found to be 40.1% with standard deviation 3.142 in post test. The obtained \"t\" value 17.385 is greater than the table value at 0.01 level of significance. Therefore, \"t\" value is found to be significant. It means there is reduction in behavioral level of nursing student. Conclusion: Study demonstrated that the planned teaching programme on ill effects selfies taking behavior on health is effective in decreasing the behavioral level of nursing students.
KEYWORDS : Effectiveness; planned teaching program; ill effects selfie-taking behavior; health; nursing students.

Paper Title

COGNITIVE BEHAVIORAL THERAPY: POST-TRAUMATIC STRESS DISORDER

Abstract

Cognitive behavioral therapy (CBT) is based on social learning theory and is one of the most widely used form of psychotherapy in research. Emphasis is placed on how the individual’s thoughts and emotions interact with their actions and assists them to develop adaptive or modify cognitions and behaviors. Cognitive behavior therapy is a collaborative and goal-oriented therapy which the clinician and patient work towards a change in mood and lifestyle. It is one of the most recommended treatment for many mental health disorders (Chand & Kuckel, 2019; & Fenn & Byrne, 2013). This paper will discuss an overview of CBT as well as include a brief discussion on its theory and practice. This writer will conclude this paper with an exploration of the effectiveness of CBT in the research of post-traumatic stress disorder (PTSD).
KEYWORDS :

Paper Title

EXPLOITING GRAPHENE MODIFIED METAL-BASED NANOCATALYSTS FOR COMMERCIALLY IMPORTANT ORGANIC TRANSFORMATIONS/REACTIONS

Abstract

This research paper discusses the potential of graphene-modified metal-based nano-catalysts in environmentally friendly organic transformations. The paper highlights the significance of replacing stoichiometric oxidants with O2 as the primary oxidant, reducing toxic by-products and waste. It also explores the role of graphene defects in enhancing catalytic activity and describes the structural modifications induced by graphene in catalytic systems
KEYWORDS :

Paper Title

DETECTION AND CLASSIFICATION OF THE PLANT DISEASE AND STRESS USING HYPERSPECTRAL IMAGE ANALYSIS TECHNIQUES

Abstract

Plant stress detection is one of the important and critical aspect in order to improve crop yield. Abiotic stress and biotic stress can affect plant growth, including water, salt, temperature, light exposure and nutrient availability. Existing methods are based on manual monitoring of field symptoms by the experts on the field which is laborious, time consuming, error prone expensive and hard to repeat. These field-based methods are also dependent upon visible signs of the stress which leads to late diagnosis of the stress. Hyperspectral remote sensing provides effective means of detecting biotic and abiotic stress even before the appearance of visual symptoms. Early detection of disease leads to early intervention in order to prevent and control the spread of the stress. By following these advancement decision makers can effectively implement and modify crop management techniques. This paper reviews the potential of hyperspectral remote sensing in prevention, detection and quantification of plant stress.
KEYWORDS : Biotic Stress, Abiotic Stress, Precision Agriculture