AIJRPLS VOL 7 ISSUE 4aerfpublications2023-03-16T10:00:13+00:00
AIJRPLS
VOLUME 7, ISSUE 4 (2022,OCT/NOV/DEC)
(ISSN-2456-3889)Online
ANVESHANA’S INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND LIFE SCIENCES
1.
FACILE SYNTHSIS OF TRIAZOLES FOR ANTIFUNGAL ACTIVITIES
G Bhaskar Reddy & Dr Praveen Kumar guide
Page 1-5
 | Paper TitleFACILE SYNTHSIS OF TRIAZOLES FOR ANTIFUNGAL ACTIVITIESAbstractA couple five membered ring systems, e.g., triazole, oxadiazole dithiazole and thiadiazole with three heteroatoms at even or unbalanced positions have been considered because of their captivating pharmacological properties. In this article our emphasis is on fabricated improvement and pharmacological development of the triazole moiety which show an extensive variety of pharmacological activity, for instance, antifungal, antibacterial, moderating and anticancer, etc. Triazoles have extended our ability to treat various infectious pollutions, for example, candidiasis, cryptococcal meningitis, aspergillosis, etc. The heterocycle molecule, in particular, with one or more 1,2,3-triazole and 1,2,4- triazoles cores has been found to have the most powerful antifungal effects. The goal of this review is to highlight recent developments in the synthesis and structure activity relationship investigation of this prospective fungicidal chemical. Also there have been explained drugs and mechanism of action of a triazole compound with antifungal activity.
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| | viewed : | 78 Downloads |
2.
CHARACTERIZATION OF MULTIDRUG RESISTANT MTB IN HYBRIDIZATION AND MUTATION
Padavala Kranthi Kumar & Dr.MASHOOD AHMAD SHAH
Page 7-11
| Paper TitleCHARACTERIZATION OF MULTIDRUG RESISTANT MTB IN HYBRIDIZATION AND MUTATIONAbstractTuberculosis is one of the major public health problems, particularly in developing countries (TB). India accounts for one-fifth of the global TB burden in terms of the total number of incident cases that occur each year. Multidrug-resistant tuberculosis (MDR-TB), which is characterized by resistance to the two most potent antituberculosis drugs, isoniazid and rifampicin, has made TB control more challenging (RMPR). India is the country with the second-highest population in the world. The country with the highest new TB cases each year is India (TB India, 2016). India contributed for 2.0–2.5 million cases, or 26% of all cases worldwide, of the anticipated 8.8 million cases in 2010. It is estimated that the TB bacillus is present in around 40% of Indians. Measures of the global TB burden according to the 2019 WHO report (rates per million persons). TB has existed for a very long period. Surprisingly, poor tuberculosis control management and a lack of fundamental knowledge might result in the development of MDR-TB and XDR-TB. Regular updates on the prevalence of drug-resistant TB and tuberculosis in general in the nation are required to guarantee that the national treatment plan for TB is successful. Given the vastness of the nation, it is conceptually challenging to survey the various geographic and environmental conditions at the national level. Resistance to different medications is the biggest threat posed by M. tuberculosis. This study is conducted to determine the prevalence of TB and multidrug-resistant tuberculosis. This study aims to analyze the genes associated with MDR-TB and to pinpoint the mutations associated with pathogenic MDR-TB strains.
KEYWORDS : MDR-TB, XDR-TB, Drugs
| | viewed : | 84 Downloads |
3.
COMPREHENSIVE LITERATURE REVIEW ON FEMALE INFERTILITY
Ashwani & Dr. Parveen Kumar
Page 12-17
| Paper TitleCOMPREHENSIVE LITERATURE REVIEW ON FEMALE INFERTILITYAbstractOne of the physical, social, and psychological pressures on society is infertility. It is described as \"the inability to establish a clinical pregnancy following a period of regular, unprotected sexual activity of at least 12 months.\" Ovulation induction has continued to be a significant step in the treatment of anovulatory infertility in women.
KEYWORDS : Women infertility
| | viewed : | 73 Downloads |
4.
PHYSICOCHEMICAL ASSESSMENT AND EFFECTS OF CONTAMINANTS PRESENT IN GROUND WATER OF BHADRA TEHSIL RAJASTHAN
Chanchal & Dr. Parveen Kumar
Page 18-27
| Paper TitlePHYSICOCHEMICAL ASSESSMENT AND EFFECTS OF CONTAMINANTS PRESENT IN GROUND WATER OF BHADRA TEHSIL RAJASTHANAbstractA Systematic study has been carried out to assess the water quality index of Bhadra tehsil of Hanumangarh district. 600 water samples from 30 stations were collected and analyzed for Physico-chemical parameters likes hydrogen ion potential, electrical conduct, alkalinity, chloride, total hardness, total dissolved Solid (pH, EC, Cl-, TH, TDS) etc respectively. Beside these parameters some ions of inorganic salts like calcium, magnesium, nitrate, fluoride, and sulfate ions are also carried out under trial respectively. The analytical data of various Physico Chemical parameters indicates that some parameters like pH, EC, TDS, TSS, Ca2+and Mg2+ are found to be in excess than the prescribed limit in some water samples of the study areas. The WQI(Water quality parameters) value indicates that water samples of some sampling stations are quite unfit for drinking purpose because of high value of Ca2+, Mg2+, and TH etc suitable suggestions were made to improve the water quality.
KEYWORDS : Water, Impurities
| | viewed : | 67 Downloads |
5.
A REVIEW ANALYSIS OF THE TREATMENT OF SERIOUS INFECTIONS OF THE SKIN AND SOFT TISSUES
Sunil Shridhar Tekale & Dr. Uttam Kumar Agarwal
Page 28-36
| Paper TitleA REVIEW ANALYSIS OF THE TREATMENT OF SERIOUS INFECTIONS OF THE SKIN AND SOFT TISSUESAbstractIntensive care, source control, and broad-spectrum antibiotics are necessary during the first stage of disease for severe SSTIs. Rapid diagnostic tests are being used more often to aid in the selection and de-escalation of antibiotics for SSTIs. Additionally, clinical prediction scores have shown potential in identifying individuals who don\'t need antibiotics that fight methicillin-resistant Staphylococcus aureus. Immune state has been shown to have a significant impact on certain forms of SSTIs, but not all. In the most current literature, the argument over the advantages of intravenous immunoglobulin is still being fought. Due to geographical differences in the most prevalent infections, patterns of antibiotic resistance, and host immune responses, severe SSTIs are frequent and their treatment is complicated. The role of surgical consultation and source control, among other particular features of treatment for severe SSTIs, are covered. Also reported are the distinctive characteristics of SSTIs in immune compromised hosts.
KEYWORDS : Gas gangrene; necrotizing fasciitis; severe skin and soft tissue infections
| | viewed : | 75 Downloads |
6.
A NARRATIVE ASSESSMENT OF THE RESEARCH ON MENOPAUSE, EMPLOYMENT AND HEALTH
Pardeep Kaur & Dr. Usha
Page 28-41
| Paper TitleA NARRATIVE ASSESSMENT OF THE RESEARCH ON MENOPAUSE, EMPLOYMENT AND HEALTHAbstractWestern women work full-time and retire later. This narrative literature analysis identifies research gaps on menopause, employment, and health. Menopause-work-health research is scarce. Themed results: Menopause and (1) not recognizing; (2) sickness absence and costs; (3) work skills; (4) job features; (5) psychological and cultural factors; (6) health; (7) mental health; and (8) coping and interventions. Menopausal symptoms might hinder employment. Organizations neglect menopause due of taboo. Menopause, work, and health research requires new theoretical and methodological approaches for global workplaces.
KEYWORDS : Workability, and health throughout menopause.
| | viewed : | 52 Downloads |
7.
A REVIEW ANALYSIS ON CREATION AND CONFIRMATION OF STABILITY SPECIFYING TECHNIQUES FOR DRUG RELATED TO RESPIRATION ILLNESSES
Kandiboti Lavanya & Dr. Priya Jain
Page 42-48
| Paper TitleA REVIEW ANALYSIS ON CREATION AND CONFIRMATION OF STABILITY SPECIFYING TECHNIQUES FOR DRUG RELATED TO RESPIRATION ILLNESSESAbstractThe review based on the creation and validation of stability indicating techniques for medications treating respiratory illnesses is the subject of the present study. The development of analytical techniques for the numerous marketable drug classes requires a thorough literature review. More straightforward and precise analytical procedures were required for the medications that had limited analytical options. The goal of the study proposal under consideration was to create and test fresh analytical techniques. Delivering straightforward, accurate, precise, focused, repeatable, reliable, cost-effective, and highly sensitive procedures is the main goal of this work.
KEYWORDS : Medications, respiratory disorders, reliable.
| | viewed : | 64 Downloads |
8.
REVIEWING SEVERAL STRATEGIES TO INCREASE THE SUCCESS OF DRUG RESEARCH AND DEVELOPMENT INITIATIVES
Mhetre Rani Mallinath & Dr. Rajendra K. Chouksey
Page 49-59
| Paper TitleREVIEWING SEVERAL STRATEGIES TO INCREASE THE SUCCESS OF DRUG RESEARCH AND DEVELOPMENT INITIATIVESAbstractNew therapeutic drugs have become more expensive and time-consuming during the last 30 years. Despite pharmaceutical companies spending in research facilities and scientific tools, efforts to increase compound flow along the drug development pipeline have mainly failed.
Non-systematic literature research identified pharmaceutical R&D success methods. The review discusses genomes and proteomics, medication repurposing and repositioning, collaborative research, underdeveloped therapeutic domains, outsourcing strategy, pharmaceutical modeling, and artificial intelligence. This method yielded the following medications. Genomics and proteomics have found numerous therapeutic targets and improved target identification and validation, reducing efficacy-related drug attrition. Phenotypic and target-based screening systems may allow serendipitous and rational drug discovery. Sharing resources and ideas decreases early drug development overhead expenses. Innovative drug targets in neglected therapeutic areas are encouraged by drug regulators.
Contract research organizations let pharma businesses focus on their strengths while outsourcing. Current and novel pharmacological modeling and artificial intelligence software and technologies allow in silico computation for more efficient computer-aided drug creation. These strategies may enhance pharmaceutical research and innovation if utilized wisely.
KEYWORDS : Target-based screening, Artificial intelligence, Proteomics, Phenotypic, Repositioning, Repurposing.
| | viewed : | 50 Downloads |
9.
REVIEW ON INDIA\'S MINOR FRUIT CROP MICROPROPAGATION
Sandhya Dungarwal & Dr. Sangeeta
Page 60-66
| Paper TitleREVIEW ON INDIA\'S MINOR FRUIT CROP MICROPROPAGATIONAbstractIn vitro plant multiplication in a short period of time utilizing any plant component (nodes, leaves, flowers, seeds, etc.) under aseptic circumstances is referred to as micro-propagation. As comparison to vegetative propagation, it is better for horticultural purposes. It is a tried-and-tested strategy for producing excess quantities of superior, identical plants in a controlled environment that are uniform, stable, free of disease, true to type, and unconstrained by seasonal constraints. Indian gooseberry (Emblica officinalis Gaertn.), Karonda (Carissa carandas L.), Bael (Aegle marmelos Corr.), Jamun (Syzygium cuminii L.), and Jackfruit (Artocarpus hetrophylous L.) are just a few of the notable but minor fruit crops native to India that have high nutritional, medicinal, and therapeutic values as well as significant commercial significance (medicinal, food and cosmetics). The commercial production procedure for these crops is constrained due to a lack of acceptable planting materials. The number of novel cultivars or genotypes of these fruit crops might be greatly increased with micropropagation. This review study\'s goal is to synthesize the body of knowledge about the micropropagation of these neglected fruit crops.
KEYWORDS : Indian gooseberry, Jackfruit, Jamun, Karonda, Micro-propagation, Minor fruit.
| | viewed : | 51 Downloads |
10.
UNDERSTANDING INDIA\'S MICRONUTRIENT SHORTAGE PROBLEM
Anu Sahdev & Dr. Kiran Kanta
Page 67-75
| Paper TitleUNDERSTANDING INDIA\'S MICRONUTRIENT SHORTAGE PROBLEMAbstractmicronutrient deficiencies worldwide, with over half residing in India. The present danger of ‘hidden hunger’ is significant in India owing to high deficiency concerns across an array of key micronutrients. A countrywide advisory board conference attended by more than 20 Indian health care experts (HCPs) was convened to obtain their clinical stance on MiND. An indepth search of PubMed articles highlighting different elements of MiND relevant to the Indian environment was undertaken and presented to notable HCPs from throughout India who subsequently gave their ideas and insights based on their clinical experiences linked with MiND.
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| | viewed : | 57 Downloads |
11.
A SYSTEM FOR GASTRO RETENTIVE DRUGM DISTRIBUTION: A REVIEW
Pradeep Singh & Dr. Sangamesh B. Puranik
Page 76-84
| Paper TitleA SYSTEM FOR GASTRO RETENTIVE DRUGM DISTRIBUTION: A REVIEWAbstractControlled-release dose formulations have improved essential pharmaceuticals. Yet, physiological issues like limiting and placing the device in the right GI tract and the highly variable stomach emptying process slow development. Bioavailability and peak plasma levels vary. Current gastroretentive drug delivery systems research was covered in this review. Gastric retention summarized physiological issues. Next, we examined high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, super porous hydrogel, and magnetic gastroretentive technologies. Gastroretentive medication administration was examined last.
KEYWORDS : Oral route, gastroretentive, and GRDDS. Different Methods
| | viewed : | 53 Downloads |
12.
STUDY ON HERBAL DRUGS THAT STIMULATE THE CENTRAL NERVOUS SYSTEM
V. Harshavardhana Reddy & Dr. Priya Jain
Page 85-91
| Paper TitleSTUDY ON HERBAL DRUGS THAT STIMULATE THE CENTRAL NERVOUS SYSTEMAbstractThis review highlights various CNS-stimulating plant species. Pharmacological classifications include psychostimulants, psychoanaleptics, and cognition enhancers. Psychostimulants like Tea, Coffee, and Cocoa temporarily increase mental and physical function (CNS). Ephedra, Khat, and St. John\'s wort are used to lose weight. Ginkgo and Gotu kola increase memory and alleviate vertigo, short-term memory loss, and attention deficit. Novel formulation creation methods for herbal CNS stimulants and botanicals in research are also discussed.
KEYWORDS : Herbal CNS stimulants, psychostimulants, psychoanaleptics, cognition enhancers
| | viewed : | 53 Downloads |
13.
COMPARATIVE ANALYSIS OF QUALITATIVE AND QUANTITATIVE PHYTOCHEMICAL EVALUATION OF SELECTED LEAVES OF MEDICINAL PLANTS
Prakash Ramrao Kadlag
Page 92-99
| Paper TitleCOMPARATIVE ANALYSIS OF QUALITATIVE AND QUANTITATIVE PHYTOCHEMICAL EVALUATION OF SELECTED LEAVES OF MEDICINAL PLANTSAbstractWhen it comes to treating numerous ailments, India\'s traditional medicine has fared better than synthetic contemporary medicine, has less side effects, and is less expensive. The current study\'s goal was to compare the qualitative and quantitative analyses of the phytochemical components of leaves from Tinospora cordifolia (Wild) Hook.f. and Murraya koenigii (L.) Spreng., both of which were obtained from Mahabaleshwar. The cold extraction method was used to extract ethanol from the powdered, shade-dried leaves. These ethanolic extracts were examined using suggested laboratory procedures for phytochemical analysis. The data were statistically analyzed using the one-way analysis of variance (ANOVA) and Tukey\'s multiple comparisons at probability value (p 0.05). Alkaloids, flavonoids, tannins, terpenoids, steroids, saponins, phenols, and glycosides were discovered by phytochemical analysis. The highest phenol and alkaloid concentrations were found in Murraya koenigii (1960.7166.88 and 19.420.26).
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| | viewed : | 53 Downloads |
14.
FORMULATION & EVALUATION DELAYED RELEASE DRUG DELIVERY SYSTEM OF NIFEDIPINE USING VARIOUS POLYMERS
Dr.R.Suthakaran & Dr.Santhisree.V
Page 100-108
| Paper TitleFORMULATION & EVALUATION DELAYED RELEASE DRUG DELIVERY SYSTEM OF NIFEDIPINE USING VARIOUS POLYMERSAbstractIn the present study an attempt was made to formulate and evaluate Nifedipine delayed release tablet using direct compression technique incorporating Natural and synthetic polymers like Tragacanth and HPMC K 100.Powder blends were evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like thickness, uniformity of weight, hardness, friability, and drug content. The results of all these tests were found to be satisfactory. The in vitro dissolution study was carried out for 12 hours using type II dissolution apparatus. Among all the formulation, N5 shows 99.38% of drug release at the end of 12 hours. This finding reveals that above a particular concentration of HPMC K 100 are capable of providing delayed drug release.
KEYWORDS : Nifedipine, Tragacanth and HPMC K 100, direct compression method and delayed release Tablets.Nifedipine, Tragacanth and HPMC K 100, direct compression method and delayed release Tablets.
| | viewed : | 56 Downloads |
15.
ANALYSIS OF THE EARTH WORM EUDRILUS EUGENIAE\'S EVOLUTION
Lagisetty Kodanda Ramulu & Dr. Kunvar Dileep Pratap Singh
Page 109-113
| Paper TitleANALYSIS OF THE EARTH WORM EUDRILUS EUGENIAE\'S EVOLUTIONAbstractEarthworm species Eudrilus Eugenia are native to Africa, but they have been widely grown in the USA, Canada, Europe, and Asia for the fish bait business, where they are known as African night crawlers. In this research, Eudrilus eugeniae was raised in cow dung and its life cycle was examined during intervals of 15, 30, 45, and 60 days. Important factors were assessed, including cocoon formation, hatchlings, total biomass, and earthworm length. After 30 days, cocoon manufacturing began, and hatchlings were released 45 days later.
KEYWORDS : Eudrilus eugeniae, Life cycle, Cow dung.
| | viewed : | 76 Downloads |
16.
AN OVERVIEW OF THE LITERATURE CONCERNING THE IDENTIFICATION OF SUSPICIOUS REGIONS IN ORAL CANCER DETECTION AT AN EARLIER STAGE
MD Shakeel Ahmad & Dr. Nirmal Sharma
Page 114-122
| Paper TitleAN OVERVIEW OF THE LITERATURE CONCERNING THE IDENTIFICATION OF SUSPICIOUS REGIONS IN ORAL CANCER DETECTION AT AN EARLIER STAGEAbstractThe major health issue of oral cancer affects people all around the globe. The majority of oral malignancies are discovered later, when therapy is less effective. Early early detection is crucial for several forms of cancer. The provision of required treatment measures that also benefit the patients is made possible by early diagnosis for surgeons. The X-rays known as dental radiographs are used to find issues with the teeth, mouth, and jaw. The many techniques that have been examined by researchers for the early detection of oral malignancies have been thoroughly reviewed in this publication. The different techniques for identifying and categorizing malignancies are contrasted. The algorithms used in each stage of the cancer detection algorithms are described.
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| | viewed : | 40 Downloads |
17.
AN INVESTIGATION INTO THE MEDICINAL FLORA OF NORTHERN GUJARAT
Swapna Kannuri & Nirmal Sharma
Page 123-130
| Paper TitleAN INVESTIGATION INTO THE MEDICINAL FLORA OF NORTHERN GUJARATAbstractThe northwest-located Aravalli district of Gujarat has a rich floral and ethnobotanical history. The tribal and rural people maintain their own traditions, customs, and complex and varied cultures. Methods: Between 2018 and 2019, an ethnobotanical study was done to document the medicinal plants used by the residents of Gujarat\'s Aravalli district in folk traditional medicine practices. This research included several field trips to the subject area. During the recurring field trips, people provided information on a variety of therapeutic plant species. Data was gathered via interviews with residents of the study region, including Bhagats, Vaidyas, priests, shepherds, and local tribal informants. Results: Further research may be done to determine the active medicinal compounds that can be utilized to treat a number of medical disorders. This study\'s researches have shed light on the native plant species used by people of the Aravalli Districts.
KEYWORDS : Aravalli Hills, Traditional medicines, Ethno medicinal plants, Folk Medicines, Gujarat.
| | viewed : | 36 Downloads |
18.
AN EXAMINATION OF THE PRESENCE OF ANTIBIOTIC-RESISTANT GENES IN MUNICIPAL WATER SUPPLY SYSTEMS
Srimathi Bai V & Dr. Nirmal Sharma
Page 131-136
| Paper TitleAN EXAMINATION OF THE PRESENCE OF ANTIBIOTIC-RESISTANT GENES IN MUNICIPAL WATER SUPPLY SYSTEMSAbstractAntibiotics are a brand-new category of pollution, and the rise of antibiotic resistance has created a worldwide health emergency. The distribution of drinking water and the purification of raw water are crucial functions of the urban water delivery system. The drinking water treatment system and the water distribution system will each be covered in this evaluation. Not all methods of water treatment can lower antibiotic resistance, according to prior studies. The network of the water supply also carries the potential danger of secondary contamination. This paper\'s study goal is to provide an overview of the prevalence and mechanism of antibiotic resistant genes (ARGs) and bacteria (ARBs) in the urban water supply system.
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| | viewed : | 45 Downloads |
