AIJRPLS VOL 7 ISSUE 3aerfpublications2023-03-16T09:00:51+00:00
AIJRPLS
VOLUME 7, ISSUE 3 (2022, JUL/AUG/SEP)
(ISSN-2456-3889)Online
ANVESHANA’S INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND LIFE SCIENCES
1.
PREPARATION OF COMMON TECHNICAL DOCUMENT FOR THE REGISTRATION OF PHARMACEUTICALS FOR HUMAN USE IN AUSTRALIA
U.Upendra Rao Inkollu.Srikanth & U. Sri Venkatesh
Page 1-7
 | Paper TitlePREPARATION OF COMMON TECHNICAL DOCUMENT FOR THE REGISTRATION OF PHARMACEUTICALS FOR HUMAN USE IN AUSTRALIAAbstractFor registration of pharmaceutical products in regulated and non-regulated market common technical document (CTD) submission is important. Common Technical document is divided into 5 modules. Module-1 contains administrative information and it is country specific. Module-2 contains overviews and summaries of 3-5 modules. Module-3 -Quality information. Module-4 contains non clinical reports. Module-5: clinical study reports
KEYWORDS : Common technical document, Module, Australia
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2.
STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR PENTAZOCIN HYDROCHLORIDE AND NALAXONE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORMS
U.Upendra Rao Patnana Swathi, & K.Rajkiran,
Page 8-13
| Paper TitleSTABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR PENTAZOCIN HYDROCHLORIDE AND NALAXONE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORMSAbstractA new method was established for estimation of Pentazocine HCl and Naloxone HCl by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Pentazocine HCl and Naloxone HCl by using Intersil ODS C18 column (250×4.6mm) 5.0µm, flow rate was 1.0 ml/min, mobile phase ratio was 30% OPA buffer: 70% Methanol (pH was adjusted 3.0 with NaoH), detection wavelength was 254 nm. The instrument used was Waters HPLC, UV detector 2450, Spinchrom -software version-2. The method shows linearity between the concentration range of 500µg/ml to 2500µg/ml for Pentazocine HCl and 5µg/ml to 25µg/ml of Naloxone HCl. The % recovery of Pentazocine Hcl and Naloxone HCl were found to be in the range of 100.1 % - 100.5 %.As there was no interference due to mobile phase, the method was found to be specific. The method was robust as observed from insignificant variation in the results of analysis by changes in flow rate and wavelength variation separately and analysis being performed by different analysts.
KEYWORDS : Pentazocine HCl, Naloxone HCl, RP-HPLC, Validation
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3.
MANAGEMENT OF ASTIGMATISM AND ITS IMPACT ON FUNCTIONAL PERFORMANCE
Prabhakar Ammannavar
Page 14-25
| Paper TitleMANAGEMENT OF ASTIGMATISM AND ITS IMPACT ON FUNCTIONAL PERFORMANCE AbstractAstigmatism is an often seen refractive disease in clinical practice. This page presents a synopsis of the research that has been undertaken on various aspects of refractive error. We examine the several facets of astigmatism, as well as research on the occurrence of astigmatic refractive errors and the natural evolution of these defects over a lifetime. This page also discusses the occurrence of astigmatism among various racial and ethnic groupings, as well as illnesses and syndromes.
We stress the extensive studies conducted on the possible genesis of astigmatism. In spite of these efforts, no model or explanation for the origin of astigmatism has been conclusively verified. Several possibilities on the genesis of astigmatism are considered, including those based on inheritance, tension in the extraocular muscles, visual input, and eyelid pressure.
The evaluation of these hypotheses is based on observations and data obtained from the relevant research literature, both in support of and in opposition to the hypotheses. Recent technical developments, including as wave front sensors and video keratoscopes, have enhanced our knowledge of ocular astigmatism. If technological progress is permitted to continue, our knowledge of astigmatism and the elements that lead to its development should also continue to grow.
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4.
PREPARATION AND EVALUATION OF ACEBUTOLOL MUCOADHESIVE FILMS
Dr. S. Jyothi Sri & D. Kusuma
Page 26-37
| Paper TitlePREPARATION AND EVALUATION OF ACEBUTOLOL MUCOADHESIVE FILMSAbstractMucoadhesive drug delivery offers a safe and easy method of drug utilization, because drug absorption can be promptly terminated in case of toxicity by removing the dosage form. A mucoadhesive film for systemic administration of Acebutolol has been developed using HPMC K4M, HPMC E5, HPMC E15, Carbopol and Eudragit and ethanol by solvent casting method. The prepared films characterized by means of film thickness, swelling capacity, Disintegration, drug release, weight variation, folding endurance, etc. The in vitro disintegration time and dissolution time of the optimized formulation (F12) was found to be 9 seconds and 99.23 % within 8 mins respectively. FTIR studies showed no drug polymer interaction takes place. These results revealed that mucoadhesive films of Acebutolol could be formulated for immediate drug release to ensure symptomatic relief which leads to improved patient compliance in the management of hypertension.
KEYWORDS : Acebutolol, Solvent casting, HPMC E15, FTIR, Mucoadhesive, Carbopol.
| | viewed : | 66 Downloads |
5.
PREPARATION AND EVALUATION OF LANSOPRAZOLE NANOSPONGES
R. NAZEMOON & A. VIJAYA RANI
Page 38-46
| Paper TitlePREPARATION AND EVALUATION OF LANSOPRAZOLE NANOSPONGESAbstractDrug delivery technology has created renewed interest in pharmaceuticals by giving them a fresh term of life through therapeutic objectives. Targeting medicine delivery has become a key issue in recent years. Which the researchers are dealing with. Drug with a specific target administration resulting in increased therapeutic effectiveness, Side effects will be reduced, and the dosing schedule will be adjusted.be the most recent developments in the field of medicines. Because of its potential for controlled drug delivery, nanosponges have emerged as one of science\'s most promising technologies.
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6.
POST COVID-19 CONDITION OR LONG COVID EFFECTS ON HUMAN
R. NAZEMOON & A. Vamshi Krishna
Page 47-51
| Paper TitlePOST COVID-19 CONDITION OR LONG COVID EFFECTS ON HUMANAbstractMost people who develop COVID-19 fully recover, but current evidence suggests approximately 10%- 20% of people experience a variety of mid- and long-term effects after they recover from their initial illness. These mid- and long-term effects are collectively known as post COVID-19 condition or “long COVID.”
As per recent data, people infected with COVID- 19 (coronavirus) may experience mild symptoms or completely asymptomatic. How long the coronavirus lasts in the body depends upon person to person, exposure to the virus and severity of infection. And also, the recovery depends upon the person health.
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7.
A STUDY ON VARIOUS GENETIC DISORDERS
| Paper TitleA STUDY ON VARIOUS GENETIC DISORDERSAbstractQualities are the structure blocks of heredity. They are passed from parent to youngster. They hold DNA, the directions for making proteins. Proteins do the greater part of the work in cells. They move particles starting with one spot then onto the next, form structures, separate poisons, and do numerous other support occupations.
Once in a while there is a transformation, an adjustment of a quality or qualities. The transformation changes the quality\'s guidelines for making a protein, so the protein doesn\'t work as expected or is missing completely. This can cause an ailment called a hereditary issue.
You can acquire a quality transformation from one or the two guardians. A transformation can likewise occur during your lifetime.
KEYWORDS : Genetic,Heridity,Transformation
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8.
A BRIEF ON CENTRAL THEMES OF BIOLOGY
Nampelly Shiva krishna
Page 57-62
| Paper TitleA BRIEF ON CENTRAL THEMES OF BIOLOGYAbstractFrom amoebas to baboons, all living things have a few things in common. Five central themes of biology set the living apart from the inanimate. Take viruses: They seem to be alive, but many biologists don\'t consider them so since they lack one or more of these unifying characteristics. Here are the factors that help distinguish the living from the not-so-living.
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9.
STUDY ON NANO FORMULATION RESEARCH AND DEVELOPMENT FOR TOPICAL SKIN INFECTION THERAPY
Sunil Shridhar Tekale & Dr. Uttam Kumar Agarwal
Page 63-71
| Paper TitleSTUDY ON NANO FORMULATION RESEARCH AND DEVELOPMENT FOR TOPICAL SKIN INFECTION THERAPYAbstractThis study develops, optimizes, and tests AZA-loaded lipid nanocarriers to increase skin targeting and retention. Pure AZA tested antibacterial and pure. AZA-loaded nano-preparation was improved using 33 full factorial design after melt emulsification and ultra-sonication.S14 (SLNs) and N23 (NLCS) were optimum with 200 nm in 27 Design runs. During physiochemical evaluation, SLNs and NLCs had zeta potential values of -13.2+1.02 and -14.30.95 mV, indicating physical stability. Nanoparticles were spherical in TEM. SLNs failed stability and particle properties tests. Therefore, N23 was tested in-vitro and in-vivo. NLCs (N23) were added to aloe-carbopol gel for administration and investigated for physiochemical and anti-acne properties. The gel had optimum wetness, spreadability, and occlusivity and was non-irritating. In-vitro permeation investigations showed Nano gel increased pharmaceutical skin retention and reduced cross-skin permeability. NLC skin distribution studies showed deep fluorescence into the skin\'s deeper layers, verifying the carriers\' drug delivery ability. In rabbit and mouse skin irritation tests, nano-gels did not cause oedema, dryness, or redness. In NLC gel, Saccharomyces cerevisiae cytotoxicity tests indicated less than 10% cell mortality. In-vivo mice ear tests showed that nano gels were more anti-inflammatory and anti-microbial than commercial treatments. Thus, NLCS gel increased tissue targeting and retention without compromising medication safety or effectiveness.
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10.
WELLBEING DIFFICULTIES AND THE EXECUTIVES OF MENOPAUSAL PROGRESS IN LADIES
Pardeep Kaur & Dr. Usha
Page 72-78
| Paper TitleWELLBEING DIFFICULTIES AND THE EXECUTIVES OF MENOPAUSAL PROGRESS IN LADIESAbstractThe end of menstruation happens at the same time as the beginning of menopause, which happens when ovarian follicular activity stops. This is what causes menopause. A clinical diagnosis of menopause may be established after a period of 12 months during which the last menstrual cycle has occurred. There are three distinct ways that menopause may come about: naturally, via surgical intervention, or through medicinal treatment. The proportion of women who are now in the middle years of their lives is growing at a much faster pace. It was estimated that there were 467 million women in the globe who were 50 or older in the year 1990, and it is forecast that this number would grow to over 1200 million by the year 2030. The majority of women experience menopause between the ages of 40 and 58. This age range accounts for the bulk of instances. In Iran, women enter menopause at a much younger age than in the United States, where the average age of menopause is 51 years. The current life expectancy of women means that they will spend approximately one third of their lives in post menopause, which may have an impact on both their quality of life and their physical health. Since menopause is a natural part of the ageing process, it is important for women to take care of their bodies during this time.
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11.
A SYSTEMATICAL EXAMINATION CONCERNING THE DIAGNOSIS AND PREDICTION OF ORAL CANCER USING VARIOUS TECHNIQUES
MD Shakeel Ahmad & Dr. Nirmal Sharma
Page 79-87
| Paper TitleA SYSTEMATICAL EXAMINATION CONCERNING THE DIAGNOSIS AND PREDICTION OF ORAL CANCER USING VARIOUS TECHNIQUESAbstractOne of the most dangerous and irrecoverable cancers which exists in the oral fissure is oral cancer or mouth cancer. It arises from the oral cavity and neck. It disturbs lips and the main parts of tongue, mouth roof and floor. It also affects our oropharynx. The principal factors for increasing mouth cancer is excessive use of tobacco, alcohol, cigarettes and human papilloma virus (HPV) infection. The diagnosis of oral cancer at an initial stage with precise treatment can save the survival of numerous people. This work provides a systematic review of diagnostic and prognostic of Oral Caner using machine learning techniques and highlights certain limits and concerns of clinicians towards the application of machine learning-based models for daily clinical practice.
KEYWORDS : Deep learning, Data mining, Oral cancer, Squamous cell, Classification.
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12.
ANALYSIS OF ETHNOBOTANICAL RESEARCH ON TRADITIONAL MEDICINAL PLANTS
Swapna Kannuri & Nirmal Sharma
Page 88-96
| Paper TitleANALYSIS OF ETHNOBOTANICAL RESEARCH ON TRADITIONAL MEDICINAL PLANTSAbstractThis article offers a thorough examination of the ethnobotanical data discovered in and around the Indian Aravalli area. The Aravalli region has a long history of using these healing plants to cure many human illnesses. By conducting a thorough and well-organized review of the data gathered from the local residents (i.e., natives, tribal groups, and elders who are knowledgeable about the plant species grown in their region), this paper aims to investigate the various plant species with ethnobotanical significance. Because natural vegetation and backyard gardens were the main sources of plant species, we may infer their inherent characteristics using inferred analysis. The most often used plant species were herbs, followed by trees. Leaves and roots were the two materials that were most common. The most popular preparatory technique was crushing. The most common routes of medication delivery were oral and cutaneous. A considerable number of medicinal plants are in danger due to drought that follows agricultural growth. The majority of medicinal plants that were marketed on the market were used for non-medical uses. In order to fully exploit plants endowed with an abundance of secondary metabolites, this knowledge of a plant\'s ethnomedical value is being passed on to the next generation.
KEYWORDS : Ethno botany; Medicinal Plants; Gujarat; Aravalli District; Tribal Communities
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13.
A LOOK AT TECHNOLOGIES RANGING FROM THE MOST COMMON TO THE MOST RECENT AND INNOVATIVE AVAILABLE TO PURIFY DRINKING WATER
Srimathi Bai V & Dr. Nirmal Sharma
Page 97-105
| Paper TitleA LOOK AT TECHNOLOGIES RANGING FROM THE MOST COMMON TO THE MOST RECENT AND INNOVATIVE AVAILABLE TO PURIFY DRINKING WATERAbstractThe most common and important liquid on earth, water is essential to all living forms. Purification of drinking water is becoming more difficult due to the expansion of industrialization, urbanization, and other human activities that have left drinking water susceptible. The purification techniques covered in this article range from the traditional ones that use activated carbon, activated alumina, silica, diatomaceous earth, etc. to the most recent ones that use nanomaterials, carbon nanotubes, and nanocomposites. Thin films, quantum dots, and aerogels are recognized as ground-breaking methods for the filtration of drinking water. Combining approaches is seen to be more advantageous than utilizing just one method since each has benefits and disadvantages in terms of efficiency, cost effectiveness, and pollutant removal.
KEYWORDS : Adsorbents, activated carbon, diatoms, nano materials, carbon nanotubes, nano composites, thin films, quantum dots.
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14.
ROLE OF HOMOCYSTEINE IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASE
Mr. Naresh Kumar Shringi
Page 106-109
| Paper TitleROLE OF HOMOCYSTEINE IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASEAbstractHomocysteine has been under a lot of speculation since its discovery in 1932. Recent years have shown a dramatic increase in research towards the better understanding of the notoriety of this amino acid of interest.
Homocysteine is an amino acid and breakdown product of protein metabolism that, when present in high concentrations, has been linked to an increased risk of heart attacks and strokes. Elevated homocysteine levels are thought to contribute to plaque formation by damaging arterial walls.
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