Paper Title

POLYHERBAL FORMULATION: A PROMISING APPROACH FOR DETERMINING PHARMACOLOGICAL ACTIVITIES AND THERAPEUTIC USES

Abstract

In Ayurveda, drug definition depends on two standards: single-drug use and numerous medication use, the last option of which is known as PHF. Polypharmacy or polyherbalism is a key customary helpful natural procedure that includes consolidating a few restorative spices to increment remedial viability. The chance of polyherbalism is interested to Ayurveda despite the fact that figuring out as far as current boundaries is fascinating. The Ayurvedic composing Sarangdhar Samhita shaded the chance of polyherbal to accomplish more imperative supportive practicality. The polyherbal plan has been used commonly around the earth in view of its supportive and medicinal application. It has been seen a polyherbal treatment or zest mix. The unique phytochemical constituents of individual plants are insufficient to achieve the positive medicinal effects. The unique constituents used from the singular plants are missing to give charming pharmacological action. In articulations of pharmacokinetic synergism, the restriction of zest to work with the absorption, scattering, assimilation and, removal of various flavors is locked in. Pharmaco-elements synergism of course focuses on the synergistic effect when dynamic constituents with near supportive development are centered around a different arrangement of action. The ongoing overview wraps all of the enormous components of the polyherbal plan.
KEYWORDS : Polyherbal, Herbs medicine, Herbal formulation, Polyherbal therapy, Phytotherapy, PHF (Poly-herbal Formulation), polyherbal formulation, Swertia chiratia, Curcuma longa, Pharmaco-dynamics.

Paper Title

CATALYTIC POTENTIAL OF ENVIRONMENTALLY-FRIENDLY METAL NANOPARTICLES SYNTHESIZED THROUGH SUSTAINABLE METHODS: REVIEW

Abstract

Nanotechnology is a rapidly advancing field with extensive applications spanning across disciplines, including science, engineering, healthcare, and pharmaceuticals. Within the myriad of techniques employed for nanoparticle production, the utilization of green technologies stands out as a straightforward and environmentally friendly approach. Nanoparticles synthesized from plant extracts have gained significant prominence in recent decades due to their multitude of advantages, such as cost-effectiveness, product stability, and eco-friendly processes. The accessibility and versatility of plant-derived nanoparticles have fostered research into their synthesis, with a growing interest in employing alternative sources, including bacteria, fungi, algae, proteins, enzymes, and more. These resources offer the prospect of large-scale nanoparticle production with minimal environmental impact. Nevertheless, nanoparticles originating from plant extracts and phytochemicals exhibit superior reduction and stabilization properties, underpinning their diverse range of attributes. These attributes encompass catalyst and photocatalyst capabilities, magnetic properties, antibacterial effects, cytotoxicity, binding to circulating tumor deoxyribonucleic acid (CT-DNA), gas sensing, and more. In the contemporary context, nanoparticles have a pivotal role to play in wastewater treatment, rendering it suitable for various applications. Nanosized photocatalysts, in particular, hold significant promise for the elimination of substantial pollutants, including organic dyes, heavy metals, and pesticides, from industrial effluents in an ecofriendly and sustainable manner. In light of these developments, this review article delves into the synthesis of diverse metal nanoparticles utilizing various plant extracts. It also explores the comprehensive characterization of these nanoparticles using techniques such as UV-Vis spectroscopy (ultraviolet-visible), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and more. Furthermore, the review provides insights into the catalytic activities of these nanoparticles in addressing a range of hazardous scenarios.
KEYWORDS :

Paper Title

ETHICAL AND LEGAL ISSUES IN MEDICAL PRACTICE

Abstract

Rapid developments in the medical field in the last century have revolutionized the field of medical practice. It is now possible to diagnose diseases faster and more accurately using advanced diagnostic techniques. Surgical treatment has moved towards less invasive modes of management with lesser morbidity and faster recovery. Among all these developments, the medical profession in India is at crossroads facing many ethical and legal challenges in the practice of the profession.
KEYWORDS : Medico legal issues, non malefecience, fundamental values

Paper Title

METHOD DEVELOPMENT AND METHOD VALIDATION OF GLIMEPIRIDE IN FORMULATION BY HPLC IN REVERSE PHASE METHOD

Abstract

The study is focused on developing a modest, quick, validated high performance liquid chromatographic (HPLC) method for glimepiride tablets from their dosage forms. The detection was carried out at 250 nm using Waters HPLC PDA detector system. The accuracy and precision were determined and validated statistically. The linearity was observed in the range of 10-200 µg/ML with a correlation coefficient of 0.999. The limit of detection and the limit of quantification were found to be 10 ng and 20 ng respectively. A (Cogent RP-C18 column with a mobile phase consisting of acetonitrile and 0.1 % formic acetic acid (55:45 v/v) was used. The mobile flow rate was 1.000 mL/min, The HPLC method is selective, precise, and accurate and can be used for routine analysis of preparation in pharmaceutical industry quality control laboratories
KEYWORDS : HPLC, Glimepiride, Tablets, Method development and validation

Paper Title

HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION OF ROSUVASTATIN CALCIUM API

Abstract

A simple and specific liquid chromatographic method was developed and validated to the analysis of Rosuvastatin Calcium API content using the HPLC. All the parameters were determined according to ICH guide lines. The detection wavelength of eluent is 254 nm, MeOH and water (90:10) are used as mobile phases by isocratic elution and a MICROSOLV make Cogent ABX C18 5µ 100Ao (150×4.6mm) Part Number: 85528-15P column is used for the separation with a flow rate 1.0 ml/min at ambient temperature to obtain good chromatographic separation results. The linearity data obtained for the concentration ranges from 200 µg to 10 µg obtained a linear curve. The response of the rosuvastatin calcium is linear at 10% to 200%. The correlation coefficient is greater than 0.99. The developed method is validated as per ICH guidelines for the parameters of linearity, suitability, LOD & LOQ, precision and robustness.
KEYWORDS : Rosuvastatin calcium, isocratic elution, ambient temperature.

Paper Title

THE IMPACT OF CORE STRENGTHENING ON LEG EXTENSION STRENGTH AMONG RUNNERS WITH PATELLOFEMORAL PAIN: A PHYSIOTHERAPY INTERVENTION

Abstract

Core stability, also known as core strength, is the ability to keep your spine and torso in a neutral position while sending the most possible motion to your extremities. By stabilising the spine over the pelvis, a person with a strong core may generate force, transfer it, and control it at the end of an integrated kinetic chain. A person\'s \"core\" consists of their spinal cord, pelvis, upper legs, and stomach. The pelvic floor and hip girdle muscles serve as the base of the box, while the diaphragm provides the top. These muscles not only physically stabilise the spine, but also transport and transmit stresses of various types, including compression, translation, and shear, to and from the rest of the body. Not just among athletes, but also in clinical rehabilitation for extremity-related disorders, the importance of core strengthening and core stability training cannot be overstated. It is possible for the lumbo-pelvic-hip complex to swiftly recover from imbalances when it is stable.
KEYWORDS : Runner\'s knee, patellofemoral discomfort, and core strength are all terms used to describe the same condition.

Paper Title

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CARBAMAZEPINE BY HPLC IN REVERSE PHASE METHOD

Abstract

Carbamazepine (CBZ), which was developed as an anticonvulsant drug, is also used as an anti-depressive, anti-analgesic, antiepileptic and antimanic drug. Carbamazepine method was developed and validated by RP-HPLC instrument. All parameters were determined with respect to ICH guidelines. Carbamazepine method developed and validated under isocratic conditions by using mobile phase consist of methanol and water ratio 80:20 v/v by using different columns. The assay was performed using Cogent C18 AR (150*4.6, 3µm, 100 A°) Pot no. 68318-15P, no peak interference was observed with run time of 10.00 min by 0.5 ml/min flow rate. System suitability reported as retention time is 3.64 min and peak area of 23,87,313.8 and linearity was obeyed in the range of 0.5 – 40 µg/1ml. The calibration curve was found to be linear with the equation y = 235438X, with correlation coefficient of 0.998098 (r) and Regression coefficient (R2) of 0.9962 over a concentration range of 0.5-40 µg/ml. And limit of detection is 0.0852 µg/ml, limit of quantification is 0.0258 µg under 0.5 ml/min flow condition.
KEYWORDS : Carbamazepine, Isocratic elution, Development and Validation by RP-HPLC.

Paper Title

RISPERIDONE WAS DEVELOPED AND VALIDATED BY REVERSE PHASE METHOD

Abstract

A simple and specific liquid chromatographic method was developed and validated to the analysis of Risperidone API content using the RP-HPLC. All the parameters were determined according to ICH guidelines. The detection wavelength of eluent is 254 nm, MeoH and ammonium formate (Ph: 3.0 with OPA) in the ratio 90:10 was used as mobile phases by isocratic elution and C18 150 × 4.6 mm 3 µm part number 68315-15P column is used for separation with a flow rate 1.0 mL/min at ambient temperature to obtain good chromatographic separation results. The linearity data obtained for the concentration ranges from 20 µg to 100 µg obtained a linear curve. It is clear that the response of the risperidone is linear at 20% to 100%. The correlation coefficient is greater than 0.99. The developed method is validated as per ICH guidelines for the parameters of system suitability, linearity, precision, LOD & LOQ and robustness.
KEYWORDS : Risperidone, Isocratic elution, ambient temperature.

Paper Title

HYPERSPECTRAL REMOTE SENSING AND ITS APPLICATIONS IN AGRICULTURE

Abstract

Hyperspectral remote sensing or imaging spectroscopy has provided precise monitoring of land. Improved tools, technology and methods have improved utilization of remotely sensed data. Traditional multispectral remote sensing data have many limitations in providing spectral data and hence it leads to the loss of crucial crop features. Hyperspectral remote sensing provides spectral data from 400 nm to 2700 nm range which provides accurate spectral information which helps precise mapping and quantification. Moreover, techniques based on hyperspectral remote sensing are less time consuming, non-destructive and easy to repeat unlike field survey-based techniques. In country like India, hyperspectral remote sensing has emerged with great possibilities of precision agriculture. With the use of hyperspectral remote sensing data estimation of biophysical and biochemical properties of crops like leaf area index, estimation of chlorophyll a and b, nitrogen, lignin, cellulose has become precise and quick. This paper includes and elaborates advantages of using hyperspectral remote sensing data.
KEYWORDS : Imaging Spectroscopy, leaf area index, multispectral data.

Paper Title

A GENERAL REVIEW ON QUANTITATIVE AND MOLECULAR GENETICS ALONG WITH THE STUDY OF HUMEN BEHAVIOUR

Abstract

There are different ways in which researchers can study the contribution that genetic factors make to human behaviour. First, there are observational studies, which involve assessing and comparing relatives such as twins or siblings, families and adopted children. This type of research is called quantitative genetics because it aims to examine the extent to which variation in a trait is influenced by genetic factors in a population. It uses statistical methods to examine and compare groups of people, without focusing on particular genes. Secondly, researchers can try to identify differences in genes that contribute to trait variation in characteristics or traits between individuals. This type of research is called molecular genetics and its application to behavioural research is explained in the current paper. it also includes study of molecular genetics researchers .in some extent we try to study about behavioural genetics.
KEYWORDS : Molecular genetics, Behavioural genetics, Quantitative genetics, Research

Paper Title

ASSESSMENT AND STANDARDIZATION OF HERBAL TREATMENTS FOR RHEUMATOID ARTHRITIS: A COMPREHENSIVE REVIEW

Abstract

Various pharmacological interventions may be utilized for arthritis treatment when non-pharmacological therapy is insufficient. However, pharmacological therapy can be associated with serious side effects and high costs. Herbal medications have shown the potential for safe and effective management of arthritis. For this review, we attempt to summarize the mechanisms, safety, and efficacy of herbal treatments for OA and RA. After searching electronic databases, we identified nine herbs among 23 clinical trials used for the treatment of OA or RA patients. Improvement of OA and RA symptoms, pain, and inflammation was demonstrated. Though these herbs have shown promise for OA and RA treatment, more studies and clinical trials are required for determining safety and efficacy, bioactivity, and optimal bioavailability. This suggests considerable continuity in the clinical application of these herbs between classical and modern Chinese medicine practice. Of the 15 herbs most frequently used as ingredients of the classical formulas, all have received research attention, and all have been reported to have anti-inflammatory effects. Nevertheless, there remains considerable scope for further research. This text-mining approach was effective in identifying multiple natural product candidates for future research.
KEYWORDS : pharmacological interventions, Ayurveda, Herbal medications, pharmacological therapy, bioactivity, natural product, herbal treatments.

Paper Title

A PRE EXPERIMENTAL STUDY TO ASSESS THE EFFECTIVENESS OF INFORMATION BOOKLET ON QUALITY OF LIFE AMONG PATIENTS COMING FOR HEMODIALYSIS IN SELECTED HOSPITALS DAHOT CITY GUJARAT

Abstract

Quality of life is actually an approach towards life. It focuses on the whole person by interacting with his /her Physical, Psychological, Social and environmental aspects rather than focusing on illness or specific parts of the body. The goal is to achieve maximum well- being, With Quality of life people accept their responsibility for their own level of wellbeingandeverydaychoicesisusedtotakechargeofone‟sownhealth.Qualityoflife (QOL) is a broad multidimensional concept that usually includes subjective evaluations of both positive and negative aspects of life. Here the investigator tries to correlate the effectiveness of information booklet in improving the quality of life.
KEYWORDS : World Health Organization, QOL: Quality of life, HRQOL: Health related quality of life, CKD: Chronic Kidney Disease, ESRD: End Stage Kidney Disease, RRT: Renal Replacement Therapy

Paper Title

A QUASI EXPERIMENTAL STUDY TO ASSESS THE EFFECTIVENESS OF EXPOSURE AND RESPONSE PREVENTION THERAPY AMONG OBSESSIVE COMPULSIVE DISORDER PATIENTS IN SELECTED HOSPITALS OF INDORE

Abstract

This study was conducted to find out the efficacy of exposure and response prevention therapy in the treatment of obsessive compulsive disorder. The \"exposure\" part of this treatment involved direct or imagined controlled exposure to the objects or situations that triggered obsessions which arouse anxiety. Over time, exposure to obsessional cues leaded to less and less anxiety. Eventually, exposure to the obsessional cue aroused little anxiety at all. This process of getting \"used to\" obsessional cues is called \"habituation.
KEYWORDS : E.R.P -Exposure and response prevention therapy, O.C.D.- Obsessive compulsive disorder, Y-BOCs,-Yale-Brown obsessive compulsive scale, SUDs- Subjective unit of distress scale, CBT- Cognitive behavior therapy, MCT- Meta-cognitive therapy.