Paper Title

ANALYTICAL VALIDATION METHOD OF ANTIHYPERLIPIDEMIC DRUG USING RPHPLC

Abstract

This study describes the analytical validation of a reverse-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous quantification of two antihyperlipidemic drugs, Pravastatin Sodium and Fenofibrate. The method was developed and validated following the guidelines of the International Conference on Harmonization (ICH) for specificity, linearity, accuracy, precision, robustness, and system suitability. The RP-HPLC method utilized an appropriate stationary phase and optimized mobile phase composition for efficient separation and quantification of Pravastatin Sodium and Fenofibrate. Specificity was demonstrated by analyzing the drugs in the presence of potential impurities and excipients commonly found in pharmaceutical formulations. Linearity was evaluated over a range of concentrations, and accuracy and precision were assessed through recovery studies and repeatability tests, respectively. Robustness of the method was evaluated by varying chromatographic conditions such as flow rate, column temperature, and mobile phase composition. System suitability parameters were determined to ensure consistent performance of the chromatographic system. The validated RP-HPLC method exhibited satisfactory results in terms of specificity, linearity, accuracy, precision, robustness, and system suitability, indicating its suitability for routine analysis of Pravastatin Sodium and Fenofibrate in pharmaceutical formulations. This validated method can serve as a reliable tool for quality control purposes in the pharmaceutical industry, particularly in the development and manufacturing of antihyperlipidemic drug products.
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Paper Title

A STUDY TO ASSESS THE EFFECTIVENESS OF VENTILATOR BUNDLE ON PREVENTION OF VENTILATOR ASSOCIATED PNEUMONIA AMONG PATIENTS ON MECHANICAL VENTILATOR AT SELECTED HOSPITALS

Abstract

The respiratory system allows for the inhalation of gases such as oxygen in the air which can then be transported by the blood around the body to supply tissues and cells, and the exhalation of waste gases such as carbon dioxide into the air. The goals of the respiration are to provide oxygen to tissues and to remove carbon dioxide. The physiology of respiration involves the following three processes: 1) ventilation, or the movement of air between the atmosphere and the alveoli 2) diffusion of oxygen and carbon dioxide between the pulmonary capillaries and the alveoli and 3) transport of oxygen and carbon dioxide in the blood to and from the 2 cells. During ventilation, the movement of air into the lungs is known as inhalation and the movement of air out of the lungs is known as exhalation.
KEYWORDS : VAP: Ventilator Associated Pneumonia , CPIS: Clinical Pulmonary Infection Score, ABG: Arterial Blood Gas, ICU: Intensive Care Unit, SICU: Surgical Intensive Care Unit, IMCU: Intensive Medical Care Unit, ARDS: Acute Respiratory Distress Syndrome, COPD: Chronic Obstructive Pulmonary Disease, ETT : Endotracheal Tube, CDC Centre for Disease Control And Prevention, WHO: World Health Organization, NHSH: National Healthcare Safety Network CNS Central Nervous System.

Paper Title

A STUDY TO ASSESS THE EFFECTIVENESS OF ASANA AND PRANAYAMA TO REDUCE DEPRESSION AND MENTAL STRESS REGARDING PHYSICAL CHANGES AND ACADEMIC PRESSURE AMONG ADOLESCENTS

Abstract

Mental health is a integral aspect of health. WHO define health as”, health is complete state of physical, mental, social and spiritual wellbeing not mealy absence of infirmity” Alma Atta commission declared India as a signatory state they declared the slogan as “Health for all till 2000 A.D.” then extended till 2010 but still India is not declared as healthy nation. Now it is declared 2030.According to WHO data presented on 28 sept. 2020 One in six people are aged 10-19yrs. Global burden of mental illness among adolescents is 16% Half of mental illnesses started at age of 14yrs but most of that are undetected and untreatable. Suicide is 4 leading cause of death among adolescents
KEYWORDS : Stress, Mental Health, Attitude, Knowledge, Structured Teaching Program, Effectiveness and Patients.