Paper Title

A DISCUSSION ON THE EFFECTIVENESS AND THE SAFETY OF ORAL DIABETES MEDICATION

Abstract

Oral type 2 diabetic medicines have been approved recently. To maximize oral diabetic medicine therapy, you must understand the efficacy and safety of new and older treatments. DPP-4 inhibitors are one of the newest oral hypoglycemic/antihyperglycemic drugs. Compared to metformin, the conventional treatment, they have less adverse effects and are moderately successful. They work well with other oral drugs including insulin. They are recommended when metformin is limited by GI side effects if SU treatment produces significant hypoglycemia or weight gain. AGIs and meglitinide analogs are limited by frequency, cost, and hypoglycemia (repaglinide > nateglinide). BAS and bromocriptine, which have GI side effects but low hypoglycemic risk, cut HbA1c the least.
KEYWORDS : α-glucosidase inhibitor; bile-acid sequestrant; bromocriptine; DPP-4 inhibitor; meglitinide; metformin; sulfonylurea; thiazolidinedione; type 2 diabetes

Paper Title

EVALUATION OF INVITRO ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF HEMEDESMUS INDICUS EXTRACT OF WHOLE PLANTS

Abstract

The present research study highlights the antibacterial and antioxidant activities of Hemedesmus Indicus root extract. The coarsely powder of Hemedesmus Indicus root was subjected to invitro antibacterial activity, the ethanolic extract of root at a concentration of 50mg/ml was tested against gram negative bacteria Klebsiella Pneumonia (ATCC33495), Pseudomons Aeruginosa (ATCC10662), Escherichia Coli (ATCC10536), Bacillus Subtilis (ATCC11774), Staphylococcus Aereus (ATCCBAA1026) and the zone of inhibition was compared with standard drug Gentamicin 20 ug /ml. The Hemedesmus Indicus root extract at a concentration of 100 ug/ml was tested for its free its free radical scavenging activity adopting various methods like DPPH, Nitric oxide and reducing power assay. The extract exhibited significant antioxidant activity after comparing with standard drug gallic acid and the results were tabulated.
KEYWORDS : Hemedesmus Indicus, Gentamicin, Gallic Acid, Antibacterial and Antioxidant Activity.

Paper Title

COMPOSITION, CHARACTERIZATION, AND ANTIMICROBIAL ACTIVITY OF POLYHERBAL PHIZ CREAM FOR WRINKLE AND ACNE TREATMENT CONTRAST NATURAL AND SYNTHETIC ELEMENTS BESIDE THE LEVIGATION TECHNIQUE

Abstract

The study was designed with the aim to find out the antimicrobial activity of Palmitic acid for the treatment of acne. Palmitic acid is long chain fatty acid with a 16-carbon backbone more over it has antibacterial activity towards gram positive and gram-negative bacteria followed by chacterization of polyherbal phiz cream was studied with various parameters such as color, odor thermal stability, homogeneity, spread ability. The Phiz cream was prepared by using combination of natural and synthetic elements by aid of Levigation technology. The best formulation was optimized among nine different formulations with different concentrations of ingredients and the results was describe as formulation code-B2. It was considered as it has shown Spreadibility of 13.3mm and pH 7.5, Viscosity-18.40cps, Dilution of 50% sparingly soluble with acid value of 2.46 and saponification value of 2.52 all this results are not far from the standard value hence the formulation B2 is considered as best formulation at last it was concluded as by using Ylang Ylang powder, geranium oil, Haworthia, Gasteria Succulent, in different ratio to get polyherbal multipurpose effect as whitening, anti-wrinkle,anti aging,and sunscreen effect on skin. These studies has concluded that the composition used here are safer and stable hence it may produce synergistic action.
KEYWORDS : Haworthia, Gasteria, Levigation technology, anti-wrinkle, Ylang Ylang powder

Paper Title

ADVANCED UPLC TECHNIQUES FOR MONITORING DRUG LEVELS IN ALLERGY AND IMMUNE SYSTEM TREATMENT

Abstract

The precise monitoring of drug levels is essential in ensuring the efficacy and safety of treatments for allergies and immune system disorders. Ultra-Performance Liquid Chromatography (UPLC) has emerged as a powerful analytical technique for accurately quantifying drug concentrations in complex biological matrices. This review focuses on the application of advanced UPLC techniques in monitoring drug levels during allergy and immune system treatment. The review begins by introducing the significance of drug level monitoring in allergy and immune system therapy, emphasizing the importance of maintaining optimal drug concentrations to achieve therapeutic outcomes while minimizing adverse effects. It highlights the limitations of conventional analytical methods and justifies the adoption of UPLC due to its high sensitivity, speed, and ability to handle complex samples.
KEYWORDS : UPLC, UPLC-MS/MS, drug monitoring, allergy treatment, immune system treatment.

Paper Title

A STUDY ON HOME CARE MANAGEMENT OF CHILDREN WITH CEREBRAL PALSY AMONG MOTHERS OF AFFECTED CHILDREN

Abstract

This review was directed To assess the viability of video helped showing on information and disposition with respect to labor planning among primi moms in tertiary consideration medical clinic, to survey the pre-test and post-test level of information and demeanor on labor arrangement among primi moms in the trial and control bunch, to assess the adequacy of video assised showing on labor readiness among primi moms in the exploratory gathering, to connect the general improvement in the degree of information and mentality of primi moms on labor readiness in the test bunch and to relate the information and mentality on labor planning among primi moms and their chose segment factors. At the first visit, the participant was informed of the study\'s goal and given written consent in writing. The specialist acquainted her with the members and afterward the device was controlled. The questionnaire was returned after 20 minutes, and the participant will receive an appropriately explained and well-designed Video Assisted Teaching on antenatal, intranatal, and postnatal care the following day. The same questionnaire schedule was used for the subsequent visit\'s posttest. Utilizing spellbinding and inferential measurements, the gathered information were analyzed and it inferred that the video helped instructing assisted with giving satisfactory information and foster ideal demeanor in regards to labor readiness among primi moms.
KEYWORDS : Effectiveness of video, cerebral palsy (CP), postnatal care, Video Assisted Teaching, inferential statistics, primi mothers.

Paper Title

TO ANALYSE THE EFFECTIVENESS OF VIDEO ASSISTED PROGRAM ON HOME CARE MANAGEMENT OF CHILDREN WITH CEREBRAL PALSY

Abstract

The overall prevalence of cerebral palsy (CP) has remained constant at 1.96 per 1000 live births over the past few years, despite an increase in the survival rate of infants born at a low birth weight. CP is the biggest demonstrative gathering treated in pediatric restoration. Social support, freedom and self-viability are confined in kids with CP as they experience impediments in the execution of everyday exercises. Around 60% of kids somewhere in the range of 4 and 16 years definitely disapprove of viable utilization of the arm and hand during reach, handle, delivery and control of items, bringing about restrictions in execution of day to day exercises. The majority of upper extremity interventions currently used aim to improve independence-oriented abilities and functionality. High training intensity and meaningful goal-directed and task-specific training are the key components for effective treatment, according to studies of these interventions. Important setting for kids to learn new day to day exercises is generally the home climate, and mediations gave in this setting are called locally established programs. \"therapeutic activities that the child performs with parental assistance in the home environment with the goal to achieve desired health outcomes\" is the definition of home-based programs. Locally situated programs are believed to be a helpful expansion or even substitution of focus based treatment in the recovery of youngsters with CP. Locally established developers\' give an extraordinary chance to prepare ceaselessly, and explicit undertakings are prepared in an important setting. Additionally, these programs allow parents to incorporate training into their child\'s daily routine, reducing the need for separate training sessions, encouraging generalization, and increasing the intensity and repetition of trained tasks, all of which contribute to effective motor learning. What\'s more, expanded measure of preparing may work with maintenance of laid out intercession impacts. Besides, it might likewise increment parental association and strengthening, thus adding to equal organizations among guardians and wellbeing experts.
KEYWORDS : Cerebral palsy (CP), spastic diplegia, spastic hemiplegia, spastic quadriplegia, extrapyramidal, spasticity, physiotherapy.

Paper Title

PFIZER AND THE CHALLENGES OF THE GLOBAL PHARMACEUTICAL INDUSTRY A STUDY

Abstract

India\'s pharmaceutical sector is currently worth $50 billion. India is a significant exporter of Drugs, with over 200+ nations served by Indian pharma sends out. India supplies more than half of Africa\'s necessity for generics, ~40% of conventional interest in the US and ~25% of all medication in the UK. India likewise represents ~60% of worldwide immunization interest, and is a main provider of DPT, BCG and Measles antibodies. 70% of WHO\'s antibodies (according to the fundamental Inoculation plan) are obtained from India. This Contextual analysis characterizes the worldwide drug industry and its \"limits\", examinations the productivity/appeal of the worldwide drug industry by utilizing M.E.Porters\' Five-Powers Model and answers the inquiries what by and large industry patterns can be distinguished and how the productivity/engaging quality of the business will change from now on. Moreover it makes sense of and assesses Pfizer\'s new procedure and analyzes what Pfizer did in the new years to keep up with their benefit.
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Paper Title

FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF PREGABALIN

Abstract

The present investigation concerns the development of Gastro retentive floating tablets of Captopril. floating tablets of Captopril was formulated by using Ethyl cellulose, Isapgol husk and Fenugreek extract as a polymeric matrix forming materials in various concentrations to study their ability to retard the release. All the formulations showed good flow properties such as angle of repose, bulk density and tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F5 formulation showed maximum % drug release i.e., 99.35 % in 12 hours. Hence it is considered as optimized formulation F5 which contains Isapgol husk. It followed Zero order release mechanism.
KEYWORDS : Captopril, Isapgol, Fenugreek, Ethyl cellulose, Gastro retentive floating tablets.

Paper Title

PREPARATION AND EVALUATION OF FLOATING TABLETS OF TRAMADOL HYDROCHLORIDE

Abstract

The purpose of this research was to formulate and evaluate the Floating sustained release tablets of Tramadol Hydrochloride 50mg, opioid pain medication. Tramadol Hydrochloride is a medication used to treat moderate to moderately severe pain. The tablets are prepared by direct compression method. The formulations were optimized by incorporating varying composition of Eudragit RSPO, HPMC K 100, Chitosan and Micro crystalline cellulose as diluent, Sodium bicarbonate as floating agents, Magnesium stearate agent as lubricant. All the excipients are tested for compatibility with drug, which revealed that there was no physical and chemical interaction occurred. The Preformulation parameters such as bulk density, tapped density, compressibility index and Hausner’s ratio were analyzed. The thickness, hardness, friability, weight variation, and drug content uniformity was evaluated for tablets. The effect of these variables on drug release also studied. The In-Vitro drug release studied were Performed in the USP dissolution apparatus-II (Paddle) using 0.1N HCL buffer as dissolution media at 50 rpm speed and temperature of 37°C ± 5°C. The sampling was done at periodic time intervals of 0.5,1,2,3,4,5,6,7,8,9,10,11 and 12 hours and was replaced by equal volume of dissolution media after each withdrawal. The cumulative amount of drug release at different intervals is estimated using UV spectrophotometer. Based on the evaluation result the formulations F-3 containing Eudragit RSPO were selected as best formulation. The tablets were found to follow Higuchi kinetics mechanism of drug release.
KEYWORDS : Tramadol Hydrochloride, Eudragit RSPO, HPMC K 100, Chitosan and Floating tablets.

Paper Title

TRADITION OF AYURVEDA: SIGNIFICANCE AND BASED PRACTICE IN COMPLEMENTARY AND ALTERNATIVE MEDICINE

Abstract

Ayurveda is a study of existence with a comprehensive way to deal with wellbeing and customized medication. It is quite possibly of the most seasoned clinical framework, which involves large number of clinical ideas and speculation. Strangely, Ayurveda has capacity to treat numerous constant illnesses like malignant growth, diabetes, joint pain, and asthma, which are untreatable in current medication. Tragically, because of absence of logical approval in different ideas, this valuable gift from our progenitors is following. Consequently, proof based research is profoundly required for worldwide acknowledgment and acknowledgment of Ayurveda, which needs further headways in the exploration system. The current survey features different fields of exploration including abstract, key, medication, drug, and clinical examination in Ayurveda. The audit further concentrations to further develop the examination technique for Ayurveda with primary accentuation on the major exploration. This endeavor will surely urge youthful analysts to chip away at different areas of examination for the turn of events and advancement of Ayurveda.
KEYWORDS : Complementary and alternative medicine (CAM), traditional Indian medicinal system, Ayurvedic research and methodology, personalized medicine, Rasayana, traditional medicine.

Paper Title

FORMULATION, DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF VILDAGLIPTIN

Abstract

The most important cause of this lookup come to be to make bigger and consider Vildagliptin\'s aid community tablets. Vildagliptin is an oral hypoglycemic professional and a member of the dipeptidyl peptidase-4 (DPP-4) inhibitor classification of medicinal drugs (diabetic medicinal drug). The medicinal drug is added regionally or systemically at a set rate for a set duration of time; this is referred to as a \"preserve discharge strategy.\" The on the spot stress approach was once employed to gather the communal pill out of transport retardant polymers such sodium CMC, acacia, and tragacanth. The powder blends in Carr\'s lookup exhibit applicable outcomes after being uncovered to a range of pre-strain constraints, such as rest, mass thickness, and tapped thickness. Submit-pressure constraints, such as weight fluctuation, thickness, hardness, friability, medicinal drug content, and in- vitro disintegration experiments, are subsequent assessed for the compacted capsules. We carried out in vitro disintegration checks on each the V3 and pH 6.8 phosphoric cushion plans for a whole of 12 hours, first with 0.1 N HCL for the first two hours and then with the impartial pH 6.8 phosphate buffer for the closing 10 hours. Results confirmed that V3 or pH 6.8 phosphoric cushion plans had most fulfilling disintegration patterns for regulating drug release. A system with a higher awareness of sodium CMC polymer helped to maintain drug launch for twelve hours. Energy is based totally on the elevated concept, with the zero- request discharge power as its focal point.
KEYWORDS : Tablets containing acacia, sodium CMC, vildagliptin, tragacanth, and supported discharge grid.

Paper Title

A STUDY ON ANTI-HEPATOTOXIC EFFECT OF BAHUINIA TOMENTOSA LINN AGAINST PARACETAMOL

Abstract

The requirement for a remedy from the natural business is a typical component since compound prompted hepatotoxicity is a significant danger to human existence in the present current world. Indeed, even medications that are not difficult to get hold of and promptly accessible can cause incidental effects when utilized nonsensically. Bauhinia tomentosa Linn is an individual from the fabaceae family and is believed to be one such potential specialist that contains many synthetic mixtures with both remedial and cure properties. In this review, Bahuinia tomentosa Linn was separated utilizing ethyl liquor, and the subsequent ethanolic extricate was tried for its capacity to safeguard pale skinned person mice\'s livers from Acetaminophen-actuated liver harm. The biochemical appraisal, histo fanatical assessments are filled in as record for the assessment of hepatoprotective development.
KEYWORDS : Bahuinia tomentosa, Hepatoprotective, Paracetamol toxicity.

Paper Title

AN EVALUATION INVITRO ANTIOXIDANT ACTIVITY OF HEMEDESMUS INDICUS ROOT EXTRACT BY DPPH METHOD

Abstract

For Hemedesmus indicus, in vitro antibacterial activity was assessed using root extract. In addition, the antioxidant potential of the root extract was evaluated using the DPPH method, nitric oxide scavenging activity, and reducing power assay method. Furthermore, the anti-inflammatory activity was determined through protein denaturation and HRBC membrane stabilization methods. The in vivo analgesic and anti-inflammatory effects of Hemedesmus indicus root extract were examined using various animal models, including the tail flick method, hot plate method, and acetic acid-induced writhing responses method. Similarly, for Justicia Betonica, preliminary phytochemical tests were performed, followed by in vitro antibacterial activity evaluation of the root extract. The antioxidant activity of the extract was assessed using the DPPH method, nitric oxide scavenging activity, and reducing power assay method. The anti-inflammatory potential was investigated through protein denaturation and HRBC membrane stabilization methods. The in vivo analgesic and anti-inflammatory effects of Justicia Betonica root extract were examined using the tail flick method, hot plate method, and acetic acid-induced writhing responses method.
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Paper Title

IMPACT OF BIBLIOTHERAPY IN REDUCING THE ANXIETY AMONG ORPHAN CHILDREN IN SELECTED ORPHANAGES OF BANGALORE

Abstract

Background: India has an orphan crisis. India has about three times the American population living in one third of the space. On the streets, children are disturbingly vulnerable; evil adults will cripple orphaned children in order to use them for works such as sexual abuse, physical violence, begging and many more just for monetary benefits. Methods: The approach used for this study was evaluative research approach. The independent variable of the study is bibliotherapy for orphan children (10-14 years) and dependent variable is level anxiety experienced by the orphan children (10-14 years). The structured anxiety assessment statements were used to collect data and were analyzed and interpreted using descriptive and inferential statistics. Results: The majority (90%) had Moderate anxiety and (10%) had mild anxiety in pre test, whereas (100%) had mild anxiety in post test. The overall anxiety scores of respondents were found to be 53.63% with standard deviation 7.9 in pre test. The overall anxiety cores of respondents were found to be 38.24% with standard deviation 7.3 in post test. It is evident that the obtained \"t\" value 26.11 is greater than the table value at 0.01 level of significance. Therefore, \"t\" value is found to be significant Conclusion: The present study was attempted to assess the impact of bibliotherapy on reduction of level of anxiety experienced by orphan children and concluded that there is reduction in level of anxiety among orphan children after exposure to bibliography. This supports that bibliography is effective in reduction of anxiety level among orphan children.
KEYWORDS : Influence; Bibliotherapy; anxiety; orphan children; orphanages.

Paper Title

A STUDY ON PROVISION FOR THE PREVENTION OF ADULTERATION OF FOOD

Abstract

Food corruption alludes to the change of food quality that happens purposely. It incorporates the expansion of fixings to change various properties of food items for financial benefit. Variety, appearance, taste, weight, volume, and timeframe of realistic usability are such food properties. Food defilement is a huge general wellbeing concern, presenting dangers to customers around the world. This exposition investigates the anticipation of food contaminated, zeroing in on causes, outcomes, and preventive measures. The causes incorporate financial intentions, frail guidelines, store network intricacy, and buyer interest for minimal expense items. Outcomes envelop wellbeing chances, wholesome inadequacies, monetary effects, and moral worries. Preventive measures include fortifying guidelines and implementation, improving testing and quality control, advancing public mindfulness, reinforcing inventory network the executives, cultivating worldwide participation, and empowering dependable strategic policies.
KEYWORDS : Food adulteration, prevention, public health, regulations, testing, supply chain management, awareness, consequences.

Paper Title

DESIGN AND DEVELOPMENT OF LOVASTATIN MOUTH DISSOLVING TABLETS BY USING NOVEL SUPER DISINTEGRANTS

Abstract

The present study is intended to develop the lovastatin fast dissolving tablets using superdisintegrants to improve the dissolution rate. Lovastatin fast dissolving tablets were prepared using direct compression method and were characterized for both pre-compression and post-compression parameters. One of the approaches is formulation of rapidly disintegrating tablets. These are useful for pediatric, geriatric and also dysphagic patients, leading to improved patient compliance. From the in vitro drug release studies the F9 tablets showed fast disintegration (38 sec) and almost complete drug release within the 10 min. The percent drug release in 10 min (Q10) and initial dissolution rate (IDR) of F9 tablets was 97.56±0.56%, 9.76%/min. These were very much higher compared to control tablets (38.41±0.23%, 3.841%/min). The relative dissolution rate (RDR) was found to be 2.93. The dissolution efficiency (DE) was found to be 43.26 and it is increased by 3.0 fold with F9 tablets when compared to control tablets. DSC and FTIR studies were carried out to understand the drug-polymer compatibility and revealed that there was no possible interaction between them. From the stability studies, F9 formulation showed the good stability and it was proved by calculating the similarity factor i.e., 82.56. Thus the developed fast dissolving tablets may be suitable to give rapid dissolution and rapid onset of action.
KEYWORDS : Lovastatin, Dissolution efficiency, Initial dissolution rate, Pre-compression parameters, Post-compression parameters, Similarity factor, Super-disintegrants.

Paper Title

TO DEVELOP NANOPARTICLE FORMULATIONS OF THE PIROXICAM MEDICATION UTILISING VARIOUS POLYMERS

Abstract

Nanoparticles are formulated to target the drug to the specific organ site and to control the rate of delivery of drug. By encapsulating a drug into nanostructures, the being of the drug in the systemic circulation can be prolonged and decrease the toxicity. The main aim of this study is to achieve prolonged release of Piroxicam such that the dosing frequency of the drug can be reduced by which we may decrease the side effects and improve the patient compliance. Investigation of the preparation, characterization and in-vitro delivery of the nanoparticles was carried out. Eight different formulations with different concentration of drug-polymer and surfactant were prepared and evaluation were done like in vitro drug release, kinetic studies and stability studies. Nanoparticles were then characterized for entrapment efficiency, percent yield, particle size analysis, morphological characteristics, and in vitro drug release the prepared particles showed good drug-loading capacity. Formulation (F-4) showed the highest encapsulation efficiency. It was concluded that F4 formulation is the optimized formulation.
KEYWORDS : Piroxicam, polymers, solvent evaporation technique, Franz diffusion cell, encapsulation efficiency stability studies.

Paper Title

A STUDY ON THE PHARMACOLOGICAL ACTIVITY AND EFFICACY OF A POLYHERBAL FORMULATION FROM MEDICINAL PLANTS

Abstract

Poly natural details have been a vital piece of conventional medication frameworks for quite a long time, offering an all encompassing way to deal with medical care. This study means to decide the pharmacological exercises of a poly natural definition made out of chosen restorative plants. The detailing was ready by consolidating removes from plants known for their restorative properties, and its pharmacological exercises were assessed through a progression of in vitro and in vivo tries. In the in vitro stage, the poly natural definition was exposed to different measures to evaluate its likely exercises, including cell reinforcement, mitigating, antimicrobial, and catalyst hindrance. The outcomes showed huge cell reinforcement potential, with a striking decrease in oxidative pressure markers. In addition, the definition showed mitigating impacts by repressing key fiery middle people. The antimicrobial measure uncovered expansive range action against both Gram-positive and Gram-negative microscopic organisms. Moving into the in vivo stage, creature models were utilized to additionally explore the pharmacological exercises. The definition showed pain relieving impacts in a torment model, with a critical expansion in torment edge noticed.
KEYWORDS : Vitro phase, Poly herbal, medicinal plants, anti-inflammatory, antimicrobial, antioxidant potential, pharmacological, animal models.

Paper Title

THE EFFECT OF A NURSE-LED TRANSITIONAL EMPOWERMENT PROGRAM FOR VETERAN-HIGH SCHOOL SENIOR: A CO-MENTORING PROGRAM

Abstract

The Effect of A Nurse-led Transitional Empowerment Program for High School Seniors and the home-bound veteran: A Co-mentoring Program utilizing a holistic approach to provide services, and improve outcomes for participants. The high school senior and the veteran post deployment commonly are in transition as their roles evolve into new roles. Transition for both parties will signal a life changing process with a potential to challenge or overwhelm their coping mechanisms unless conscious effort is made to adequately prepare them for this change process. The high school senior will be graduating from high school and either going onto college or not, while the veteran will be in post deployment and for re-integration to civilian role. Both will undergo a huge change process but the pathways may be undefined and uncertain overtime. The aim of this study is to examine the effectiveness of a nurse-led transitional empowerment program through the formation of a Veteran-High School Senior partnership that uses a holistic approach and compared to a usual veteran transitional re-integration program. The program will combine intensive skills training with mentoring, recreational activities and creative projects and also integrate primary health prevention and referral services versus standard transitional veteran re-integration program. It will run through a twelve month period during which the effectiveness will be measured using survey instruments. The survey instruments will include the quality of life scale which will measure the general life satisfaction, the activities of daily living scale which measures functional status and the decision making scale which measures their general empowerment. The data will be collected at baseline (first month), midway (six months) and at the end (twelve months) of the study. The results of this study will contribute to health policy, nursing research, and veteran’s recovery and re-integration program outcomes.
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Paper Title

MIXED LIGAND METAL-ORGANIC FRAMEWORKS OF SELECTED METAL IONS: SYNTHESIS AND CRYSTAL STRUCTURAL INVESTIGATION

Abstract

In the pursuit of designing Metal-Organic Frameworks (MOFs) with precisely predictable network topologies, our research has focused on the synthesis of novel multidentate ligands. These ligands, in combination with commercially available multidentate ligands, have enabled the construction of MOF structures. We have successfully complexed these MOFs with transition metal ions and alkaline earth metals, resulting in the formation of coordination polymeric structures with potential applications as porous materials. The design of our ligands is unique in that it prevents the formation of homoleptic metal complexes, instead facilitating the coordination of multiple metal atoms to create open framework structures replete with void spaces. The MOFs synthesized in our studies currently contain solvents and ligands within their cavities, suggesting their potential as host-guest systems. These frameworks hold promise in selectively capturing harmful compounds such as pollutants and toxicants. To further enhance the functionality of these MOFs, we are exploring the functionalization of the organic ligands. This endeavor aims to introduce specific reactive or binding sites at well-defined and controllable positions within the network topology
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