Paper Title

MECHANISTIC INSIGHTS INTO THE ANTI-INFLAMMATORY AND ANTI-ARTHRITIC POTENTIAL OF PHYTOCHEMICAL-RICH MEDICINAL PLANT EXTRACTS

Abstract

Rheumatoid arthritis (RA) is a progressive autoimmune inflammatory disorder characterized by synovial hyperplasia, cytokine overexpression, oxidative stress, and irreversible joint destruction. Although synthetic anti-inflammatory drugs remain the primary treatment modality, their prolonged use leads to severe systemic complications. Phytochemical-rich medicinal plants represent a promising multi-target therapeutic strategy due to their antioxidant, immunomodulatory, and cytokine-suppressive properties. The present study investigates mechanistic aspects of anti-arthritic activity of selected medicinal plant extracts through phytochemical characterization, antioxidant profiling, protein denaturation inhibition, and membrane stabilization assays. The extracts demonstrated significant radical scavenging activity (IC50 = 46 µg/mL), inhibition of protein denaturation (81.9%), and stabilization of erythrocyte membranes (78.3%) at 500 µg/mL concentration. Statistical evaluation confirmed significant efficacy (p < 0.05). Mechanistic interpretation suggests modulation of NF-κB signaling pathway, inhibition of pro-inflammatory cytokines, and reduction of oxidative stress. These findings support further pharmacological and molecular investigations toward development of plant-based disease-modifying anti-rheumatic agents.
KEYWORDS : Rheumatoid arthritis, NF-κB inhibition, Cytokines, Oxidative stress, Phytochemicals, Anti-inflammatory activity.

Paper Title

AN EXPLORATORY STUDY TO ASSESS THE KNOWLEDGE AND PRACTICE OF PRIMARY SCHOOL TEACHERS REGARDING COMMUNICATION PROBLEMS AMONG PRE-SCHOOl CHILDREN, IN ORDER TO DEVELOP INFORMATION BOOKLET ON COMMUNICATION SKILL

Abstract

A communication problem refers to \"an impairment in the ability to receive, send, process, and comprehend concepts or verbal, nonverbal, and graphic symbol systems\". Normal development of communication requires the interaction of an intact mechanism with a favorable environment. The components of an intact mechanism include hearing sensitivity, perception, intelligence, structural integrity, motor skill, and emotional stability. A favorable environment is one that provides the child with adequate language exposure and stimulation, reinforces the child\'s communicative attempts, and holds realistic expectations according to the child\'s developmental stage. Children with communication problems frequently do not perform at grade level. They may struggle with reading, have difficulty understanding and expressing language, misunderstand social cues, avoid attending school, show poor judgment, and have difficulty with tests. Difficulty in learning to listen, speak, read, or write can result from problems in language development. Problems can occur in the production, comprehension, and awareness of language sounds, syllables, words, sentences, and conversation. Individuals with reading and writing problems also may have trouble using language to communicate, think, and learn. Parents and teachers should refer any student who shows signs of a speech-language problem or delay to the school-based child study team. Screening, assessment, and treatment of communication problems may involve cooperative efforts.
KEYWORDS : Knowledge, Practice, Primary school teachers, communication problems, Pre-school children

Paper Title

ANALYSING EFFICACY OF YOGA INTERVENTION ON THE PHYSICAL AND MENTAL HEALTH OF ADULTS WITH TYPE II DIABETES

Abstract

A growing body of research suggests that yoga can be an effective supplementary treatment for a range of medical issues, including type II diabetes. This article summarizes research that looked at the effects of yoga on the emotional and physical well-being of people who have type II diabetes. The researchers used a randomized prospective interventional strategy. The research lasted for six months. Individuals were chosen for the study based on predetermined inclusion and exclusion lists. For as long as three months, those who were part of the intervention group practiced yoga twice a week. There was a wide range of asanas and pranayama practised throughout each 35-minute yoga session. The results show that glycemic control, as assessed by HbA1c levels, fasting blood glucose, and postprandial blood glucose, can be significantly improved with yoga intervention. Blood pressure and lipid profiles, two indicators of cardiovascular health, were also found to improve with regular yoga practice.When asked about their mental health, participants said they felt better overall and had less stress, anxiety, and sadness. These beneficial effects may be due, in part, to yoga\'s holistic approach, which addresses the whole person (mind and body).
KEYWORDS : Yoga, Type II diabetes Mental, Physical, Patients.

Paper Title

A STUDY ON THE PSYCHOPHYSIOLOGICAL EFFECTS OF HATHA YOGA IN PSYCHOSOMATIC ILLNESS THERAPY

Abstract

Researchers in the Indian state of Bihar set out to learn more about the physiological and psychological benefits of Hatha Yoga for those with psychosomatic diseases. Conditions such as hypertension, irritable bowel syndrome (IBS), and migraine are examples of psychosomatic disorders, which are defined by the impact of psychological variables on physical health. Some believe that Hatha Yoga, with its emphasis on the integration of mind and body, can have a beneficial effect on physiological and psychological factors, leading to a reduction in symptoms and an overall improvement in quality of life. Ninety persons, ranging in age from twenty to sixty, were surveyed. The participants included both males and females. Incorporating Hatha Yoga into the treatment of psychosomatic illnesses is the subject of this paper\'s extensive examination of demographic characteristics, intervention outcomes, and implications.
KEYWORDS : Yoga, Therapy, Health, Illnesses, Adult.