Paper Title

USE OF NANOTECHNOLOGY IN PHARMACUTICAL INDUSTRY

Introduction

This Nanotechnology is a revolutionizing drug delivery, which will have a high impact on the health care. One will need to know about the metabolism of drug and nanomedicine pharmacokinetics to achieve suitable therapeutic dosing.

Paper Title

PHYSIOLOGY AND HEALTH EDUCATION

Introduction

Physiology is in a sense the study of life, internal working of organisms and how they interact with world around them physiology tests how organs and systems with in the body work, how they speak to each other and how they combine their efforts to make conditions favorable for survival. Health is highly subjective concept a state of complete physical, mental and social well being and not the mere absence of disease or infirmity-physical health refers to automatically integrity and physiological functioning of the body, mental health ability to learn and think clearly and social health ability to make and maintaining acceptable interaction with other people. Many criteria utilize health education as primary means of prevention of diseases of promotion of health. In view of this the national health policy and health sector development program have identified health education on a major component of program service.

Paper Title

SURVEY TO DETERMINE THE AWARENESS AND KNOWLEDGE OF PUBLIC ON HEPATITIS B IN TELANGANA, INDIA

Introduction

Background: Hepatitis B virus infection (HBV) is a global public health problem with 520 million people chronically affected leading to more than one million deaths per year making viral hepatitis one of the world’s greatest health threats. According to Ministry of Health India, the average fatality rate due to viral hepatitis from 1991 to 1995 was about 9.2 per 100,000 populations. To date, there are still 5 million hepatitis B virus carriers in India and will be the source of HBV infection to others. We suspect that the current state is mainly due to lack of awareness and knowledge by the lay public. Therefore, we have embarked in this study to determine the awareness and knowledge on HBV infection among the public in the selected area of Bhongir, Telangana, India.
Method: The main objective of the study method was to assess the extent of Hepatitis B awareness and knowledge status of the participants. A cross sectional study was conducted about 400 subjects (>12 years of age) based on validated questionnaire which was distributed and completed by the respondent during the period from February 2016 to May 2016. The data was analyzed using the Statistical Package for Social Sciences (SPSS) software.
Results: Reliability test (Cronbach’s alpha) was good (> 0.731) and excellent (> 0.912) for knowledge and awareness among the subjects respectively. The results show that there is a statistically significant difference in the mean knowledge and awareness of the subjects with different age ranges (P < 0.05), different ethnic groups (P < 0.005) and different education qualifications (P < 0.005). Around 400 respondents, 135 (81.8%) of them are well known about Hepatitis B.
Conclusion: The age, education qualification and religion have an effect on the awareness and knowledge of hepatitis B among the participant. In this study all the three demographic characteristic plays a role as the predictive factor. Overall, the awareness and knowledge was found to be low and should be improved through health education and vaccination program on hepatitis B more frequently among the public especially in Hyderabad district.

Keywords : Hepatitis B, knowledge, awareness, reliability test, survey, vaccination.

Paper Title

MONOCLONAL ANTIBODIES: IMPACT OF ANTIBOITIES

Abstract

Humans have the capacity to make antibodies. It will provide the basis need of protection against the disease organisms. It also helps to target various kinds of molecules present in body such as receptors or the other proteins which present on the normal cells surface and the molecules which presents uniquely on the surface of cancer cells. These are remarkable in human therapy because they only make the antibody that will only blinds these cells of cancer in patient, for destroying these cells antibody is coupling with cytotoxic agent.
In the human body the immune manufacture system creates antibodies of a high range of different structures which are used in both their binding regions and as well as their effecting region. Because of the limited potential growth of normal somatic cells, even if we isolate a single secreting cell and place it in a culture, it will die in few generations. Now it needs a make “monoclonal antibodies” – antibodies of single specificity, they are built alike as they are manufactured by a single clone of plasma cells and that can be grown indefinitely.
B-cell secreting antibody can be cancerous like any cell. This type of proliferation unchecked cell is known to be myeloma. By the research, Milstein and Kohler have discovered a process to link the great potential of myeloma cells with the prearranged antibody particularity of immune spleen cells. They had done this by intersecting the cells of myeloma with the secreting antibody cells from an immunized mouse. The technique is called somatic cell hybridization. The result is a hybridoma.

Paper Title

THEORETICAL STUDY OF THE ELECTRONIC SPECTRA, STATIC FIRST HYPERPOLARIZABILITY AND ANTIRADICAL CAPACITY OF 2-PYRIDONE TAUTOMERS BY DENSITY FUNCTIONAL THEORY (DFT)

Abstract

The geometries, electronic structures, polarizabilities and hyperpolarizabilities of 2-Pyridone tautomers were studied based on Density Functional Theory (DFT) using the hybrid functional B3LYP. Here we explore in the Density Functional Theory (DFT) framework the antiradical activity of 2 -pyridone. Using the single charge transfer model electrodonating (ω-)and electro accepting (ω+) powers, a Donor Acceptor Map (DAM) was employed to classify them as good or bad antiradicals. Ultraviolet-visible (UV-Vis) spectrum was investigated by Time Dependent DFT (TD-DFT). Features of the electronic absorption spectrum in the visible and near-UV regions were assigned based on TDDFT calculations. Polarizability and the first order hyperpolarizability values have been computed theoretically.

Keywords : 2 – pyridone, antiradical activity, TD-DFT, polarizability and the first order hyperpolarizability.

Paper Title

ESTIMATION OF TIZANIDINE PRESENT IN TABLET FORMULATION BY RP-HPLC

Abstract

A simple, specific, accurate and precise Reverse Phase High Performance Liquid Chromatographic method was developed for estimation of Tizanidine in tablet dosage form on RP C-18 Column (BDS Hypersil 250*4.6 mm) using mobile phase as Buffer- Acetonitrile (60:40 v/v) The flow rate was 1.0 ml/min and effluent was monitored at 232nm. The retention time is 4.05 respectively. Proposed method was validated for Precision, Accuracy, Linearity range, Robustness and Ruggedness.

Keywords : Tizanidine Reverse Phase High Performance Liquid Chromatography.

Paper Title

SYNTHESIS AND MICROBIOLOGICAL ACTIVITY OF SOME SPOTLESS PYRIMIDINE DERIVATIVES

Abstract

A uncomplicated and well-organized method for synthesis of 1,2,3,4-tetrahydro pyrimidine derivatives was achieved from different acetoacetamides, 4-(2,6-difluoro-4-nitrophenoxy) Benz aldehyde and N-methylurea using few drops of conc. hydrochloric acid added and refluxed with ethanol with high yield and no further purification (Colum purification) requirement for compound . The structures of the products were supported by FTIR, 1HMR and mass spectral data and microbiological activity completed of all compounds.

Keywords : 4-(2, 6-difluoro-4-nitrophenoxy)Benz aldehyde; hydrochloric acid, N-methyl urea only refluxed.

Paper Title

PURSED LIP BREATHING EXERCISE – A SELF-MANAGEMENT APPROACH TOWARDS SHORTNESS OF BREATH

Abstract

Respiratory patient’s lung function declines as the disease progresses. Shortness of breath is the common symptom in most of the chronic respiratory conditions. As disease worsens or age advances breathlessness can occur even with minimal exertion and daily activities become more difficult. Breathing exercises are essential for patients with chronic lung diseases. Breathing exercises helps to conserve energy and promotes daily activities with less effort and less shortness of breath by increasing effectiveness of breathing. Pursed lip breathing exercise can be used by a patient when feels dyspnea, both during activities and even at rest. Pursed-lip breathing is a breathing exercise where inhalation of air slowly through nose and exhalation slowly through mouth by pursing the lips. It provides immediate symptomatic relief from breathlessness. Pursed-lip breathing primarily slows down the respiratory rate and assists in emptying the lungs of retained CO2. It helps in self-recovery from chronic respiratory symptoms. Respiratory patients learn pursed lip breathing exercise spontaneously and uses as self-management approach in daily living activities. Regularly practiced pursed lip breathing is an effective self-management stratagem for individuals with chronic lung diseases to control breathing pattern, and increases exercise capacity.

Keywords: Pursed lip breathing (PLB), Breathing exercise, Shortness of breath (SOB) and chronic respiratory diseases.

Paper Title

AYURVEDA – AN APPROACH TO CANCER PREVENTION AND TREATMENT

Introduction

Indian population is considered to be prone to various types of cancers. In 2014, WHO ranked 9th, 51st, 52nd, 75th and 95th in accordance to death caused by oral cancer, cervical cancer, esophagus cancer, stomach cancer and ovarian cancer respectively. Erroneous life style like smoking, alcoholism etc. Is considered to be a main contributing factor in keeping Indian population in the radar of cancer prone group. Cancer is a lifestyle disease and to an extend can be prevented by lifestyle modifications like consuming anti-cancerous fruits, vegetables, spices etc.
Cancer is a disease with multi-factorial etiology like life style, diet, environment etc. So contemporary medicine itself cannot provide a cure. Low prognosis, Painful chemo and radiation, and high cost make cancer treatment unsatisfactory. Ayurveda can be a ray of hope for cancer patient as it emphasizes on safe medicine, life style changes and preventive measures.

Paper Title

MODERN PRACTICES IN THE FIELD OF NURSING

Abstract

The research scholar has been associated with the Nursing profession for the past 23 years and has had the exposure of working in the capacity of Nursing Administrator. She also has had the opportunity to visit various Nursing institutions across the state of Maharashtra which has been approved by the Maharashtra University of Health Sciences [MUHS], which is considered as one of the apex bodies involved in the approval of nursing colleges.
The research topic chosen is on the basis of the experience of the research scholar and has been studied by her extensively.
She has compared the traditional methods used in the teaching as well as the introduction of modern methods on being used as well as those which could be used in the coming days.
The Researcher has drawn a logical Research Design which comprises of a descriptive survey approach, covering most of the Preceptors and students from the randomly selected Nursing colleges.
There are approximately 52 Nursing Colleges which have been established in the state of Maharashtra and they have been categorized on the basis of divisions which have been declared by the MUHS. The state has 05 divisions namely Pune, Nasik, Mumbai, Nagpur and Aurangabad.

Keywords: Nursing, Teachings, Traditional Methods, Modern Methods, Preceptors.

Paper Title

SEPARATION AND DETERMINATION OF FEXOFENADINE HYDROCHLORIDE AND MONTELUKAST SODIUM IN TABLET DOSAGE FORM USING RP-HPLC

Abstract

A simple, precise and accurate reversed-phase high-performance liquid chromatographic method has been developed and validated for the simultaneous determination of Fexofenadine hydrochloride (FEX) and Montelukast sodium (MTKT) in their synthetic mixtures and combined tablet formulation. The chromatographic separation was achieved on a Thermo BDS HYPERSIL C18 column (250mm × 4.6 mm i.d., 5 μ particle size) at ambient temperature using simple isocratic mobile phase consisting of phosphate buffer (pH 6.0) and methanol (25: 75, v/v), pumped at a flow rate of 1.0 mL min-1. UV detection was performed at 220 nm. The method was validated in the sample concentration ranges of 84–156 µg mL-1 for FEX and 7–13 µg mL-1 for MTKT, where it demonstrated good linearity with r = 0.9991 and 0.9995, respectively. The retention time (tR) for FEX and MTKT were found to be 3.542 ± 0.01 and 7.142 ± 0.01 min, respectively. The validation of the proposed method was carried out for linearity, precision, robustness, limit of detection, limit of quantitation, specificity, accuracy and system suitability. The developed method can be used for routine quality control analysis of titled drugs in pharmaceutical dosage form.

Keywords: Fexofenadine hydrochloride, Montelukast sodium, HPLC, Method development, Validation.

Paper Title

EXAMINATION OF SEED BORNE MYCOFLORA OF GROUNDNUT

Abstract

Groundnut is a valuable legume crop in india groundnut seed are contain 50% edible oil having rich in fact, proteins and vitamin, Nicotinic acid and other vitamins. The seed mycoflora of groundnut is determined by standard blotter paper and agar plate method in this determination we examine 7 genera and 12 species of fungi which are Alternariacitri, Alternariaterrus, Asporigillus flavus Aspergillus funigatus, Asperigillus niger, Aspergillus ustus, Asperigillius oxysporium Fusarium semitectum, Asperigillius niger, Fusarium oxysporium and Alternariaterrus were found predominant fungi and shows higher percentage of seed mycoflora. In this study we also examine that blotter paper method give higher percent of fungi as compared to agar plate method.

Keywords: Seed Mycoflora, Blotter paper method, Agar plate method, Predominant fungi.

Paper Title

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR THE LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE DRUGS BY RP-HPLC

Abstract

A simple Reverse phase liquid chromatographic stability indicating method for assay has been developed and subsequently validated for simultaneous determination of Losartan potassium and Hydrochlorothiazide in combination. The separation was carried out using a mobile phase of Buffer and Acetonitrile are taken in 45:55%v/v. The column used was reverse phase C18 column (3.9-mm × 15-cm; 5-µm packing L7) with flow rate of 1.0 ml min using PDA detection at 254 nm. The described method was linear over a concentration range of 25-75 μg/ml and 6.25-18.75 μg/ml for the assay of losartan potassium and hydrochlorothiazide respectively. The retention times of losartan potassium and hydrochlorothiazide were found to be 12.0 and 7.7 min respectively. Results of analysis were validated statistically and by recovery studies. Results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is stability indicating of losartan potassium and hydrochlorothiazide drugs in solid dosage form.

Keywords: Losartan potassium, Hydrochlorothiazide, stability indicating.

Paper Title

PHYSICAL PROPERTIES OF SOYABEAN

Abstract

This study was investigate the physical properties of soyabean i.e. density coefficient of fraction, size of grain, volume of grain, bulk density. The moisture content of soyabean seed is 7.57, 10.92 & 15.80% from this experiment it is investigated that the grain size of soyabean seed increases from 5.412 to 5.524 mm the grain volume increased from 79 to 82.74 mm3 whereas the sphericity increased from 0.81923 to 0.8412 which is change in moisture content i…e from 7.32 to 15.72 % (db) The bulk and true density were observed from 748.2 to 622.1 kg/m3 and from 1243 to 1110 the static coefficient of friction increased linearly against all the tested surfaces as the moisture content increased.

Keywords: Bulk porosity, Coefficient of friction, Sphericity.

Paper Title

NUTRITION VALUE OF SESAME SEED

Abstract

The aim of present study was to determine the nutritional value of sesame seed and from the determination it is observe that seasame is a rich source of protein it is seen that in twenty eight gram of sesame seed includes 0.7mg of manganese, 0.7 mg of copper 277 mg of copper 4.1 mg of Iron, 99.7 mg of Magnesium, 2 mg of Zinc, 3.9 g of Fiber, 0.7 mg of Thiamin, 0.2 mg of Vitamin, B6 179mg of Phosphorous and protein contain 4.7 g.
It is also seen that sesame seed contain important minerals and vitamins like, niacin, thiamin, same neutraceutical compounds such as phenolic & tocopherols having antioxidant properties which reduces blood prerure, chronic diseases degeneration of vessals.

Keywords: antioxidant properties, regeneration of vessels, Nutritional value.

Paper Title

SEED BORNE FUNGI OF SOYABEAN

Abstract

The present study gives the objectives of seed borne fungi of Soyabean. In this investigation about 100 Soyabean seeds are taken from the major growing area of soyabean in Vidharbha region of Maharashtra. The experiment was taken by two method which is agar plate method & blotter method. Form this investigation it is determine that the total percent of seed borne fungi of soyabean in Akola & Amravati district ranges from 32 to 48.12% and 24.10 to 46.2% by blotter method and 13.16 to 36.86% and 14.92 to 26.2% by agar plate method total nine fungal species were investigated & from which M.Phaseolina was found to be predominant and the occurance of cladosporium seen was least from the two method of seed borne fungi of soyabean for detection of seed mycoflora standard blotter method was found to be superior than Agar plate method.

Keywords: Predominant, seed Mycoflora, Agar plate method, standard blotter method.

Paper Title

IN VITRO CYTOTOXIC POTENCY OF BIS-THIAZOLIDINONES AND ITS DERIVATIVES AGAINST BRINE SHRIMP

Abstract

In the present manuscript the Brine shrimp bioassay lethality was carried out for in vitro cytotoxic measurements of synthesized Bis-Thiazolidinones and its derivatives compounds against Artemia salina. The LD50 values were calculated after probit transformation of the resulting mortality data. All the synthesized compounds are found to be promising bioactive compounds by registering their LD50 of 1.030 X 10-4, 1.179 X 10-4 and 1.472 X 10-4 which correspond to compounds 1, 2 and 3 respectively.

Paper Title

GENDER DISCRIMINATION AMONG GIRL CHILD

Abstract

The Constitution guarantees equality and prohibits discrimination on the grounds of sex. The Constitution guarantees the right to equality, right to life, prohibits discrimination and empowers the state to make special provisions for the girl child. The Government invoking these provisions have introduced various special measures. In consonance with this policy various laws have been enacted. The discriminatory provisions of law are being progressively reviewed. The National Commission for Women, the Department of Women and Child Development and the Parliamentary Committee on Empowerment of Women have reviewed various laws and recommended amendments to many of the laws with the objective of promoting equality and to amend discriminatory provisions. Despite the constitutional mandate of equal legal status for the girl child, the same is yet to be realized. The de jure laws have not been translated into de facto situation for various reasons such as illiteracy, social practices, prejudices, cultural norms based on patriarchal values, poor representation of women in policy-making, poverty, regional disparity in development, lack of access and opportunity to information and resources etc. The research paper provides the suggestion and betterment steps to discard girl discrimination.

Paper Title

STEM CELLS AND THEIR PRESERVATION AND UTILIZATION

Abstract

Stem cells are the body’s natural reservoir – replenishing stocks of specialized cells that have been used up or damaged. We all have stem cells at work inside us. Right now, inside your bone marrow, stem cells are busy making the 100,000 million new blood cells you need every single day. We need to make new cells all the time, just to keep our body functioning. Some specialized cells, such as blood and muscle cells, are unable to make copies of themselves through cell division. Instead they are replenished from populations of stem cells. Stem cells have the unique ability to produce both copies of themselves (self-renewal) and other more specialized cell types (differentiation) every time they divide. Stem cells, therefore, are essential to the maintenance of tissues such as blood, skin, and gut that undergo continuous turnover (cell replacement), and muscle, which can be built up according to the body’s needs and is often damaged during physical exertion.