Paper Title

DEVELOPMENT TECHNOLOGY AND EVALUATION OF STAVUDINE NANOPARTICLES

Abstract

In Novel Drug Delivery, Nanoparticles provides a promising drug delivery system of controlled and targeted drug release. Nanoparticles are specially designed to release the drug in the vicinity of targeted tissue. Polymeric nanoparticles have been considered as promising drug delivery systems for variety of drugs like anticancer agents, biological macromolecules and vaccines. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing the side effects. Nanoparticles mediated targeting plays an important role in inhibiting inflammation, angiogenesis and tumor progression. Especially polymeric nanoparticles have greater deal that provides numerous properties such as simple to synthesize, inexpensive, biocompatible, biodegradable, non-toxic, non-immunogenic and water soluble for an effective drug delivery and drug targeting. The main applications of nanotechnology in medicine are materials and devices for diagnosis and for drug delivery. The aim of this study is to formulate the Stavudine loaded nanoparticles of chitosan, cross linked with Tween 80 for antiretroviral therapy, in order to enhance the bioavailability and to reduce the dose frequency. Formulations of Stavudine loaded nanoparticle were prepared by double emulsion solvent evaporation and solvent diffusion methods. Fourier transmission infrared spectroscopy studies indicated no chemical interaction between drug and polymer. In vitro release studies were performed by the dialysis membrane method. All the drug loaded batches were followed first order and sustained drug release over a period of 20 hrs.
KEYWORDS : Stavudine, Nanoparticles, Double emulsion solvent evaporation and Solvent diffusion.