Paper Title
FORMULATION AND EVALUATION OF RITONAVIR TABLETS BY USING HOT MELT EXTRUSION METHODAbstract
In the pre-formulation studies, solubility, drug-excipient compatibility and flow properties of API were studied. All formulations were prepared by wet granulation method by using microcrystalline cellulose PH102, Croscarmellose sodium, povidonek30, sodium lauryl sulfate, colloidal silicon dioxidePH200, and magnesium stearate. Dry granulation batch was taken and results were compared with wet granulated batch of same composition. Film coating was done by using Opadry white YS-1-7059 to protect ritonavir from moisture. The tablets prepared were found to be within the official limits with respect to weight variation, thickness, hardness, friability, disintegration and dissolution. The stability study was performed for F6 formulation as per ICH guidelines. Stability study was carried out for 3 months at 40°C/75%RH. The tablets were tested for release and results were found within the limits. Among the all formulations the release profile of trial F6 was found to be similar to the marketed product release profile.
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