Paper Title

ANALYTICAL VALIDATION METHOD OF ANTIHYPERLIPIDEMIC DRUG USING RPHPLC

Abstract

This study describes the analytical validation of a reverse-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous quantification of two antihyperlipidemic drugs, Pravastatin Sodium and Fenofibrate. The method was developed and validated following the guidelines of the International Conference on Harmonization (ICH) for specificity, linearity, accuracy, precision, robustness, and system suitability. The RP-HPLC method utilized an appropriate stationary phase and optimized mobile phase composition for efficient separation and quantification of Pravastatin Sodium and Fenofibrate. Specificity was demonstrated by analyzing the drugs in the presence of potential impurities and excipients commonly found in pharmaceutical formulations. Linearity was evaluated over a range of concentrations, and accuracy and precision were assessed through recovery studies and repeatability tests, respectively. Robustness of the method was evaluated by varying chromatographic conditions such as flow rate, column temperature, and mobile phase composition. System suitability parameters were determined to ensure consistent performance of the chromatographic system. The validated RP-HPLC method exhibited satisfactory results in terms of specificity, linearity, accuracy, precision, robustness, and system suitability, indicating its suitability for routine analysis of Pravastatin Sodium and Fenofibrate in pharmaceutical formulations. This validated method can serve as a reliable tool for quality control purposes in the pharmaceutical industry, particularly in the development and manufacturing of antihyperlipidemic drug products.
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Paper Title

A STUDY TO ASSESS THE EFFECTIVENESS OF VENTILATOR BUNDLE ON PREVENTION OF VENTILATOR ASSOCIATED PNEUMONIA AMONG PATIENTS ON MECHANICAL VENTILATOR AT SELECTED HOSPITALS

Abstract

The respiratory system allows for the inhalation of gases such as oxygen in the air which can then be transported by the blood around the body to supply tissues and cells, and the exhalation of waste gases such as carbon dioxide into the air. The goals of the respiration are to provide oxygen to tissues and to remove carbon dioxide. The physiology of respiration involves the following three processes: 1) ventilation, or the movement of air between the atmosphere and the alveoli 2) diffusion of oxygen and carbon dioxide between the pulmonary capillaries and the alveoli and 3) transport of oxygen and carbon dioxide in the blood to and from the 2 cells. During ventilation, the movement of air into the lungs is known as inhalation and the movement of air out of the lungs is known as exhalation.
KEYWORDS : VAP: Ventilator Associated Pneumonia , CPIS: Clinical Pulmonary Infection Score, ABG: Arterial Blood Gas, ICU: Intensive Care Unit, SICU: Surgical Intensive Care Unit, IMCU: Intensive Medical Care Unit, ARDS: Acute Respiratory Distress Syndrome, COPD: Chronic Obstructive Pulmonary Disease, ETT : Endotracheal Tube, CDC Centre for Disease Control And Prevention, WHO: World Health Organization, NHSH: National Healthcare Safety Network CNS Central Nervous System.

Paper Title

A STUDY TO ASSESS THE EFFECTIVENESS OF ASANA AND PRANAYAMA TO REDUCE DEPRESSION AND MENTAL STRESS REGARDING PHYSICAL CHANGES AND ACADEMIC PRESSURE AMONG ADOLESCENTS

Abstract

Mental health is a integral aspect of health. WHO define health as”, health is complete state of physical, mental, social and spiritual wellbeing not mealy absence of infirmity” Alma Atta commission declared India as a signatory state they declared the slogan as “Health for all till 2000 A.D.” then extended till 2010 but still India is not declared as healthy nation. Now it is declared 2030.According to WHO data presented on 28 sept. 2020 One in six people are aged 10-19yrs. Global burden of mental illness among adolescents is 16% Half of mental illnesses started at age of 14yrs but most of that are undetected and untreatable. Suicide is 4 leading cause of death among adolescents
KEYWORDS : Stress, Mental Health, Attitude, Knowledge, Structured Teaching Program, Effectiveness and Patients.

Paper Title

THE ROLE OF SACRED GROVES IN BIODIVERSITY PRESERVATION IN TELANGANA

Abstract

The people of Telangana have a profound understanding of the religious and ecological importance of sacred groves, and they regard them with utmost respect. This study highlights the importance of these groves by analyzing their biodiversity. Through thorough field surveys and strong collaboration with the local community, we conducted a detailed study of the wide range of plant and animal species. Throughout the research, a wide array of uncommon and endangered species were uncovered. Our research highlights the crucial role that sacred groves play in providing a wide range of ecological services, such as soil conservation and temperature regulation. Unfortunately, these precious ecosystems face significant risks from the ever-growing pressures of industrialization and deforestation. This study presents strong evidence supporting the efficacy of policy interventions in the conservation of sacred groves by combining traditional knowledge with modern methods. Having a profound knowledge of botany and extensive experience in environmental conservation is essential. Preserving these reserves is crucial for the future of Telangana\'s natural and spiritual landscapes, as well as for protecting the state\'s rich cultural heritage and wide variety of plant and animal life.
KEYWORDS : sacred groves, biodiversity, ecological services, spiritual landscapes

Paper Title

A STUDY ON PREVENTING AND MITIGATING COMPLICATION OF DIABETES

Abstract

Diabetes is a metabolic disorder accompanied by complications of multiple organs and systems. Diabetes has become one of the largest public health problems to date. Decreased physical activity, overnutrition, and nutrition transitions caused by changes in lifestyle contribute to the increasing incidence of chronic metabolic diseases as well as deaths related to them. The shift from undernutrition to overnutrition indicates that chronic diseases of affluence have become a public health problem; hence, sustainable health-related goals have been developed for the prevention of these diseases. Environmental factors and the gut microbiota influence metabolism in the human body. Several studies have proven that lifestyle interventions can effectively deter the progression of diabetes in individuals with impaired glucose tolerance.
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Paper Title

DESIGN, DEVELOPMENT OF WAX APPLE HERBAL NANOPARTICLES

Abstract

Wax apple is a fruit which has a lot of health benefits and it\'s veritably easy to consume no efforts are taken. The extracts of the fruits, flower and bark have potent free revolutionary scavenging, antioxidation, anti-mutation and anticancer conditioning. The wax apple is an immunostimulant and antibacterial medicine in traditional drugs. It is an important tropical cash crop in Southeast Asian countries. Its scientific name is Syzygium samarangense, but it is more commonly known as Java apple. This whole plant parts are useful and have some importance to it. The growth and development of this fruit is sometimes very low due to low photosynthesis supply at early growth stages. Exportation of this plant can be tough. But with the help of advanced herbal and medicinal technology, we can make use of this fruit. This review paper has information about the wax apple with its phytoconstituents and therapeutic properties.
KEYWORDS : : wax apple, tropical tree, java apple,

Paper Title

A STUDY OF METHODS FOR ASSESSING SOIL MICROBIAL DIVERSITY

Abstract

Soil microorganisms play a major role in the decomposition of organic matter, regulation of the release of mineral nutrients, and nutrient cycling. The variety of soil microbes has been the focus of a lot of recent study. Understanding the diversity of this complex microbial community in the soil environment is a challenging task. Because of this, it\'s vital to acquire and comprehend the appropriate methods for studying soil microbial diversity. An overview of the primary research techniques and the idea of soil microbial diversity is given in this publication. The use of molecular and biochemical methods in this domain is then evaluated, including pros and cons. A survey of pertinent recent research is given, along with ideas for further examining soil microbial diversity.
KEYWORDS : Ecological Methods, Microbial Communities, Molecular Techniques

Paper Title

EXPLORING THE POTENTIAL MAIZE STARCH IN THE DEVELOPMENT OF A NOVEL CO-PROCESSED EXCIPIENT

Abstract

Starch is the main component of maize, which is produced by wet milling process. Maize starch functionality varies with the starch structure and composition, which vary with genotypes and cultural practices. The average size of maize starch granules ranges between 1 and 7 μm and 15 and 20 μm, respectively, for small- and large-sized granules. Maize relies on humans for its propagation. Since the Columbian exchange, it has become a staple food in many parts of the world, with the total production of maize surpassing that of wheat and rice. Much maize is used for animal feed, whether as grain or as the whole plant, which can either be baled or made into the more palatable silage. Maize starch, derived from corn, has found a significant place in pharmaceutical formulations due to its inherent properties. Its widespread use can be attributed to factors such as cost-effectiveness, stability, and its ability to act as a multifunctional excipient.
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