Paper Title

STUDY ON NANO FORMULATION RESEARCH AND DEVELOPMENT FOR TOPICAL SKIN INFECTION THERAPY

Abstract

This study develops, optimizes, and tests AZA-loaded lipid nanocarriers to increase skin targeting and retention. Pure AZA tested antibacterial and pure. AZA-loaded nano-preparation was improved using 33 full factorial design after melt emulsification and ultra-sonication.S14 (SLNs) and N23 (NLCS) were optimum with 200 nm in 27 Design runs. During physiochemical evaluation, SLNs and NLCs had zeta potential values of -13.2+1.02 and -14.30.95 mV, indicating physical stability. Nanoparticles were spherical in TEM. SLNs failed stability and particle properties tests. Therefore, N23 was tested in-vitro and in-vivo. NLCs (N23) were added to aloe-carbopol gel for administration and investigated for physiochemical and anti-acne properties. The gel had optimum wetness, spreadability, and occlusivity and was non-irritating. In-vitro permeation investigations showed Nano gel increased pharmaceutical skin retention and reduced cross-skin permeability. NLC skin distribution studies showed deep fluorescence into the skin\'s deeper layers, verifying the carriers\' drug delivery ability. In rabbit and mouse skin irritation tests, nano-gels did not cause oedema, dryness, or redness. In NLC gel, Saccharomyces cerevisiae cytotoxicity tests indicated less than 10% cell mortality. In-vivo mice ear tests showed that nano gels were more anti-inflammatory and anti-microbial than commercial treatments. Thus, NLCS gel increased tissue targeting and retention without compromising medication safety or effectiveness.
KEYWORDS :

Paper Title

WELLBEING DIFFICULTIES AND THE EXECUTIVES OF MENOPAUSAL PROGRESS IN LADIES

Abstract

The end of menstruation happens at the same time as the beginning of menopause, which happens when ovarian follicular activity stops. This is what causes menopause. A clinical diagnosis of menopause may be established after a period of 12 months during which the last menstrual cycle has occurred. There are three distinct ways that menopause may come about: naturally, via surgical intervention, or through medicinal treatment. The proportion of women who are now in the middle years of their lives is growing at a much faster pace. It was estimated that there were 467 million women in the globe who were 50 or older in the year 1990, and it is forecast that this number would grow to over 1200 million by the year 2030. The majority of women experience menopause between the ages of 40 and 58. This age range accounts for the bulk of instances. In Iran, women enter menopause at a much younger age than in the United States, where the average age of menopause is 51 years. The current life expectancy of women means that they will spend approximately one third of their lives in post menopause, which may have an impact on both their quality of life and their physical health. Since menopause is a natural part of the ageing process, it is important for women to take care of their bodies during this time.
KEYWORDS :

Paper Title

ROLE OF HOMOCYSTEINE IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASE

Abstract

Homocysteine has been under a lot of speculation since its discovery in 1932. Recent years have shown a dramatic increase in research towards the better understanding of the notoriety of this amino acid of interest. Homocysteine is an amino acid and breakdown product of protein metabolism that, when present in high concentrations, has been linked to an increased risk of heart attacks and strokes. Elevated homocysteine levels are thought to contribute to plaque formation by damaging arterial walls.
KEYWORDS :