Paper Title
MOLECULAR COMPLEXES OF ROSUVASTATIN CALCIUM WITH -ACCEPTORSAbstract
The molecular reaction of Rosu-Ca, with various -acceptors like tetracyanoethylene, p-chloranilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, 2,3,5,6-tetrabromo-1,4-benzoquinone, 1,3,5- trinitrobenzene, 2,3,5,6-tetrachloro-1,4-benzoquinone, 7,7,8,8-tetracyano-quinodimethane, and 2,4,7-trinitro-9-fluorenone gives CT complexes w. The donar and acceptor correlation was determined by uv-visible spectrophotometric techniques .The obtained colored complexes was use for the development of accurate spectrophotometric methods for the determination of Rosu-Ca. The absorbances, concentrations of Rosu-Ca is in the range of 2–200 g mL−1 under the optimum reaction conditions, linear relationships with good correlation coefficients (0.9984–0.9995) . The detection limit range is from 0.41 to 12.24 g mL−1. Interference could not be observed from the additives which are present in the drugs that were co-related with RoSu-Ca. These methods are successfully applied for analysis of drugs with good accuracy . The range of recovery percentages were from 99.54–100.46 ± 1.58–1.82%. The proposed methods are practical and valuable for drug analysis.
KEYWORDS : Rosuvastatin Calcium, Molecular complexes, Spectrophotometry ,HPLC, CT complexes.