Paper Title
FORMULATION AND EVALUATION OF EXTENDED RELEASE TABLETS (REPAGLINIDE)Abstract
Most conventional oral drug products, such as tablets and capsules, are formulated to release the active drug immediately after oral administration, to obtain rapid and complete systemic drug absorption. Such immediate-deliver products result in relatively rapid medication absorption and onset of accompanying Pharmacodynamic effects. However, once absorption of the medicine from the dose type is complete, plasma drug concentrations decline per the drug\'s pharmacokinetic profile. Eventually, plasma drug concentrations fall below the minimum effective plasma concentration (MEC), leading to loss of therapeutic activity. Before this time is reached, another dose is typically given if a sustained therapeutic result is desired. An alternate to administering another dose is to use a dose type that may offer sustained drug release, and so maintain plasma drug concentrations, on that fare side generally seen mistreatment immediate- release dose forms. In recent years, varied modified-release drug products are developed to manage the release rate of the drug and/or the time for drug release.
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